Cardiorespiratory function associated with dietary nitrate supplementation
Bond V, Curry BH, Adams RG, Millis RM, Haddad GE
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 30 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Institutes of Health
- Gobierno
- National Institute on Alcohol Abuse and Alcoholism
- Gobierno
- National Center for Research Resources
- Gobierno
- National Institute on Minority Health and Health Disparities
- Gobierno
- NCRR NIH HHS
- Gobierno
- NIAAA NIH HHS
- Gobierno
- NIMHD NIH HHS
- Subvenciones
- National Center for Research Resources (G12 RR003048); National Center for Research Resources (2G12-RR003048); National Institute on Minority Health and Health Disparities (G12 MD007597); National Institute on Alcohol Abuse and Alcoholism (R15 AA019816)
Según 8 financiadores declarados.
Publicación
- Publicado
- 2013-08-02 · Appl Physiol Nutr Metab · vol. 39 · número 2 · págs. 168–172
- Editorial
- NRC Research Press
- Citado
- 42 citas · más que el 98% de estudios similares · 12.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Nitric Oxide and Endothelin Effects
- Palabras clave
- Cardiorespiratory fitness, Heart rate, Blood pressure, VO2 max, Internal medicine, Medicine, Respiratory quotient, Respiratory minute volume, Endocrinology, Aerobic exercise, Cardiology, Animal science, Chemistry, Respiratory system, Biology
- MeSH
- humans, nitrates, nitric oxide, exercise test, cross-over studies, oxygen consumption, heart rate, dietary supplements, female, young adult
5 autores
- Vernon Bond🇺🇸Howard University
- Bryan H Curry🇺🇸Howard University Hospital
- Richard G. Adams🇺🇸Howard University Hospital
- Richard Mark Millis🇺🇸Howard University
- Georges E. Haddad🇺🇸Howard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
The advent of medical nutrition therapy and nutritional physiology affords the opportunity to link diet to specific cardiovascular mechanisms, suggesting novel treatments for cardiovascular disease. This study tests the hypothesis that beetroot juice increases the plasma nitric oxide (NO) concentration, which is associated with improvements in cardiorespiratory function at rest and during submaximal aerobic exercise. The subjects were 12 healthy, young adult, normotensive African-American females, with a body mass of 61 ± 2 kg, body fat of 28% ± 4%, and peak oxygen consumption of 26 ± 3 mL·kg(-1)·min(-1). The subjects were studied at rest and during cycle ergometer exercise at 40%, 60%, and 80% of peak oxygen consumption. Plasma NO concentration, respiratory quotient (RQ), minute ventilation, systolic and diastolic blood pressure (SBP and DBP), heart rate, and oxygen consumption were compared between isocaloric, isovolumetric placebo control orange juice and experimental beetroot juice treatments on separate days. The beetroot juice treatment increased plasma NO concentration and decreased oxygen consumption, SBP, and the heart rate-SBP product at rest and at 40%, 60%, and 80% of peak oxygen consumption in the absence of significant effects on RQ, minute ventilation, heart rate, and DBP. These findings suggest that, in healthy subjects, beetroot juice treatments increase plasma NO concentration and decrease cardiac afterload and myocardial oxygen demand at rest and during 3 submaximal levels of aerobic exercise. Future studies should determine the cellular and molecular mechanisms responsible for the improvement in cardiorespiratory function associated with dietary nitrate supplementation and whether they translate into better cardiovascular function and exercise tolerance in individuals with a compromised cardiovascular system.
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