Protein-enriched diet, with the use of lean red meat, combined with progressive resistance training enhances lean tissue mass and muscle strength and reduces circulating IL-6 concentrations in elderly women: a cluster randomized controlled trial
Daly RM, O'Connell SL, Mundell NL, Grimes CA, Dunstan DW, Nowson CA
The American journal of clinical nutrition · 149 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-04-01 · Am J Clin Nutr · vol. 99 · número 4 · págs. 899–910
- Editorial
- Elsevier BV
- Citado
- 205 citas · más que el 99% de estudios similares · 12.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutrition and Health in Aging · Muscle metabolism and nutrition · Muscle Physiology and Disorders
- Palabras clave
- protein-enriched diet, progressive resistance training, older women, sarcopenia, lean body mass, muscle strength, interleukin-6, systemic inflammation, insulin-like growth factor I, protein intake, vitamin D3 supplementation, retirement communities, aging, serum lipids, blood pressure, physical inactivity, low-grade inflammation, muscle function, disability prevention
- MeSH
- muscle, skeletal, animals, humans, cholecalciferol, dietary proteins, interleukin-6, combined modality therapy, cohort studies, follow-up studies, housing for the elderly, down-regulation, body composition, dietary supplements, meat, aged, aged, 80 and over, middle aged, victoria, female, muscle strength, resistance training, sarcopenia
6 autores
- Robin M. Daly🇦🇺Baker Heart and Diabetes Institute; Deakin University
- Stella L. O’Connell🇦🇺Baker Heart and Diabetes Institute
- Niamh L Mundell🇦🇺Baker Heart and Diabetes Institute
- Carley Ann Grimes🇦🇺Baker Heart and Diabetes Institute
- David W. Dunstan🇦🇺Baker Heart and Diabetes Institute
- Caryl Anne Nowson🇦🇺Baker Heart and Diabetes Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Physical inactivity, inadequate dietary protein, and low-grade systemic inflammation contribute to age-related muscle loss, impaired function, and disability.
Objective
We assessed the effects of progressive resistance training (PRT) combined with a protein-enriched diet facilitated through lean red meat on lean tissue mass (LTM), muscle size, strength and function, circulating inflammatory markers, blood pressure, and lipids in elderly women.
Design
In a 4-mo cluster randomized controlled trial, 100 women aged 60-90 y who were residing in 15 retirement villages were allocated to receive PRT with lean red meat (∼160 g cooked) to be consumed 6 d/wk [resistance training plus lean red meat (RT+Meat) group; n = 53] or control PRT [1 serving pasta or rice/d; control resistance training (CRT) group; n = 47)]. All women undertook PRT 2 times/wk and received 1000 IU vitamin D3/d.
Results
The mean (± SD) protein intake was greater in the RT+Meat group than in the CRT group throughout the study (1.3 ± 0.3 compared with 1.1 ± 0.3 g · kg⁻¹ · d⁻¹, respectively; P < 0.05). The RT+Meat group experienced greater gains in total body LTM (0.45 kg; 95% CI: 0.07, 0.84 kg), leg LTM (0.22 kg; 95% CI: 0.02, 0.42 kg), and muscle strength (18%; 95% CI: 0.03, 0.34) than did the CRT group (all P < 0.05). The RT+Meat group also experienced a 10% greater increase in serum insulin-like growth factor I (P < 0.05) and a 16% greater reduction in the proinflammatory marker interleukin-6 (IL-6) (P < 0.05) after 4 mo. There were no between-group differences for the change in blood lipids or blood pressure.
Conclusion
A protein-enriched diet equivalent to ∼1.3 g · kg⁻¹ · d⁻¹ achieved through lean red meat is safe and effective for enhancing the effects of PRT on LTM and muscle strength and reducing circulating IL-6 concentrations in elderly women. This trial was registered at the Australian Clinical Trials Registry as ACTRN12609000223235.
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