Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans
Larsen FJ, Schiffer TA, Ekblom B, Mattsson MP, Checa A, Wheelock CE, Nyström T, Lundberg JO, Weitzberg E
The American journal of clinical nutrition · 64 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-04-01 · Am J Clin Nutr · vol. 99 · número 4 · págs. 843–850
- Editorial
- Elsevier BV
- Citado
- 92 citas · más que el 98% de estudios similares · 8.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Nutritional Studies and Diet · Phytochemicals and Antioxidant Activities
- Palabras clave
- dietary nitrate, sodium nitrate, resting metabolic rate, nitrite, nitric oxide, mitochondrial respiration, myotubes, reactive oxygen species, isoprostanes, antioxidant capacity, thyroid hormones, insulin sensitivity, vegetables
- MeSH
- cells, cultured, saliva, humans, nitrates, nitrites, basal metabolism, calorimetry, indirect, diet, administration, oral, infusions, intravenous, cross-over studies, double-blind method, cell respiration, down-regulation, oxidative stress, adult, female, male, quadriceps muscle, adult stem cells, muscle fibers, skeletal, biomarkers
9 autores
- Filip Jon Larsen🇸🇪Karolinska Institutet; Stockholm South General Hospital; Swedish School of Sport and Health Sciences
- Tomas A. Schiffer🇸🇪Karolinska Institutet
- Bjorn T. Ekblom🇸🇪Karolinska Institutet
- Mathias P Mattsson🇸🇪Karolinska Institutet
- Antonio Checa🇸🇪Karolinska Institutet
- Craig E. Wheelock🇸🇪Karolinska Institutet
- Thomas Nyström🇸🇪Karolinska Institutet
- Jon O. Lundberg🇸🇪Karolinska Institutet
- Eddie Weitzberg🇸🇪Karolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Nitrate, which is an inorganic anion abundant in vegetables, increases the efficiency of isolated human mitochondria. Such an effect might be reflected in changes in the resting metabolic rate (RMR) and formation of reactive oxygen species. The bioactivation of nitrate involves its active accumulation in saliva followed by a sequential reduction to nitrite, nitric oxide, and other reactive nitrogen species.
Objective
We studied effects of inorganic nitrate, in amounts that represented a diet rich in vegetables, on the RMR in healthy volunteers.
Design
In a randomized, double-blind, crossover study, we measured the RMR by using indirect calorimetry in 13 healthy volunteers after a 3-d dietary intervention with sodium nitrate (NaNO₃) or a placebo (NaCl). The nitrate dose (0.1 mmol · kg⁻¹ · d⁻¹) corresponded to the amount in 200-300 g spinach, beetroot, lettuce, or other vegetable that was rich in nitrate. Effects of direct nitrite exposure on cell respiration were studied in cultured human primary myotubes.
Results
The RMR was 4.2% lower after nitrate compared with placebo administration, and the change correlated strongly to the degree of nitrate accumulation in saliva (r² = 0.71). The thyroid hormone status, insulin sensitivity, glucose uptake, plasma concentration of isoprostanes, and total antioxidant capacity were unaffected by nitrate. The administration of nitrite to human primary myotubes acutely inhibited respiration.
Conclusions
Dietary inorganic nitrate reduces the RMR. This effect may have implications for the regulation of metabolic function in health and disease.
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