Egg consumption and risk of GI neoplasms: dose-response meta-analysis and systematic review
Tse G, Eslick GD
European journal of nutrition · 15 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-02-05 · Eur J Nutr · vol. 53 · número 7 · págs. 1581–1590
- Editorial
- Springer Science+Business Media
- Citado
- 20 citas · más que el 49% de estudios similares · 0.5× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Colorectal Cancer Screening and Detection · Cancer Risks and Factors
- Palabras clave
- egg consumption, gastrointestinal cancer, colon cancer, dose-response relationship, dietary intake, cancer risk, dietary habits, dietary risk factors, dietary balance
- MeSH
- humans, gastrointestinal neoplasms, diet, risk factors, eggs, databases, factual
2 autores
- Genevieve Tse🇦🇺The University of Sydney; Nepean Hospital
- Guy D. Eslick🇦🇺 · autor de correspondenciaThe University of Sydney; Nepean Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Previous epidemiological studies on egg consumption and the risk of gastrointestinal (GI) neoplasms suggest a positive association; however, data are limited and the evidence remains controversial. This study aims to investigate and quantify the potential dose-response relationship with an evaluation of cancer site-specific differences.
Methods
Relevant studies were identified after the literature search via electronic databases until January 2014. Subgroup analysis for serving portions was performed using two standardized classification methods: (1) less than 3, or 3 or more eggs per week; (2) less than 3, 3-5, or more than 5 eggs per week. Method two excludes studies that only reported consumption frequency. Pooled adjusted odds ratios (ORs) comparing highest and lowest categories of dietary pattern scores were calculated using a random-effects model.
Results
Thirty-seven case-control and seven cohort studies were included for meta-analysis, which contained a total of 424,867 participants and 18,852 GI neoplasm cases. The combined odds ratio (OR) was calculated to 1.15 (95% CI 1.09-1.22; p value heterogeneity 5 eggs per week were 1.13 (95% CI 1.06-1.21; p value heterogeneity = 0.25), 1.14 (95% CI 1.01-1.29; p value heterogeneity = 0.06), and 1.19 (95% CI 1.01-1.39; p value heterogeneity <0.001), respectively.
Conclusion
This study provides evidence that egg consumption is associated with a positive dose-response association with the development of GI neoplasms.
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