The effects of caffeine ingestion on cortical areas: functional imaging study
Park CA, Kang CK, Son YD, Choi EJ, Kim SH, Oh ST, Kim YB, Park CW, Cho ZH
Magnetic resonance imaging · 28 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Ministry of Health and Welfare
- Gobierno
- National Research Foundation of Korea
- Gobierno
- Ministry of Education, Science and Technology
- Subvenciones
- Ministry of Health and Welfare (A090084); Ministry of Education, Science and Technology (NRF-2006-2005137)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2014-01-06 · Magn Reson Imaging · vol. 32 · número 4 · págs. 366–371
- Editorial
- Elsevier BV
- Citado
- 37 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 23 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Neurotransmitter Receptor Influence on Behavior · Advanced MRI Techniques and Applications
- Palabras clave
- caffeine, cognitive enhancement, attention, cortical activation, brain glucose metabolism, visuomotor task, posterior medial cortex, insula, putamen, cerebellum, thalamus, primary motor cortex, resting state
- MeSH
- brain, nerve net, humans, caffeine, central nervous system stimulants, nootropic agents, magnetic resonance imaging, brain mapping, administration, oral, cognition, adult, female, male
9 autores
- Chan-A Park🇰🇷Gachon University; Seoul National University
- Chang‐Ki Kang🇰🇷Gachon University
- Young‐Don Son🇰🇷Gachon University
- Eun‐Jung Choi🇰🇷Gachon University
- Sang‐Hoon Kim🇰🇷Gachon University
- Seung-Taek Oh🇰🇷Gachon University
- Young-Bo Kim🇰🇷Gachon University
- Chan‐Woong Park🇰🇷Gachon University; Seoul National University
- Zang‐Hee Cho🇰🇷🇺🇸 · autor de correspondenciaGachon University; University of California, Irvine
Resumen
El texto original del estudio, en el idioma en que se publicó.
The effect of caffeine as a cognitive enhancer is well known; however, caffeine-induced changes in the cortical regions are still not very clear. Therefore, in this study, we conducted an investigation of the activation and deactivation with blood-oxygenation-level-dependent (BOLD) functional magnetic resonance imaging (fMRI) and of metabolic activity change with positron emission tomography (PET) in the human brain. Fourteen healthy subjects performed a visuomotor task inducing attention with 3T MRI, and PET imaging was also carried out in seven subjects to determine the cerebral glucose metabolic changes of caffeine at rest. The result by fMRI showed increased BOLD activation in the left cerebellum, putamen, insula, thalamus and the right primary motor cortex, and decreased BOLD deactivation in the posterior medial and the left posterior lateral cortex. Also, the resting state PET data showed reduced metabolic activity in the putamen, caudate nucleus, insula, pallidum and posterior medial cortex. The common cortical regions between fMRI and PET, such as putamen, insula and posterior medial cortex, where significant changes occurred after caffeine ingestion, are well known to play an important role in cognitive function like attention. This result suggests that the effect of caffeine as a cognitive enhancer is derived by modulating the attentional areas.
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