Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review
Dibaba DT, Xun P, He K
European journal of clinical nutrition · 87 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCATS NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL081572); National Institute of Environmental Health Sciences (R01ES021735); National Center for Advancing Translational Sciences (UL1TR-001108)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-02-12 · Eur J Clin Nutr · vol. 68 · número 4 · págs. 510–516
- Editorial
- Springer Nature
- Citado
- 141 citas · más que el 84% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Alloys: Properties and Applications
- Palabras clave
- dietary magnesium, C-reactive protein, serum CRP, inflammation, chronic disease, magnesium supplementation
- MeSH
- humans, magnesium, c-reactive protein, diet, observational studies as topic
3 autores
- Daniel Tefera Dibaba🇺🇸Indiana University Bloomington; Indiana University
- Pengcheng Xun🇺🇸Indiana University Bloomington; Indiana University
- Ka He🇺🇸Indiana University Bloomington; Indiana University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
The aim of this study was to quantitatively summarize the association of dietary magnesium (Mg) intake with serum C-reactive protein (CRP) levels in the general population.
Subjects/methods
Observational and experimental studies through February 2013 were reviewed in PubMed and EMBASE. Additional information was retrieved through Google or hand search of related reference lists. The main outcome is either adjusted geometric mean of CRP or odds ratio (OR) of having serum CRP ≥ 3 mg/l. Meta-regression was used to determine the linear association of dietary Mg intake and adjusted geometric means of CRP levels. A fixed-effects model was used to pool ORs of interest, comparing those in the lowest with those in the highest group of dietary Mg intake.
Results
A data set derived from seven cross-sectional studies including 32,918 participants was quantitatively assessed. A weighted inverse association between Mg intake and serum CRP levels was observed (β-coefficient: -0.0028; 95% confidence interval (CI), -0.0043 to -0.0013; P(trend) = 0.001) from four cross-sectional studies. The pooled OR (95% CI) of having CRP ≥ 3 mg/l was 1.49 (1.18-1.89) on comparing the lowest to the highest group of Mg intake from three studies with the data available. Qualitative assessment among five intervention studies also showed a potential beneficial effect of Mg intake on serum CRP levels.
Conclusions
This meta-analysis and systematic review indicates that dietary Mg intake is significantly and inversely associated with serum CRP levels. The potential beneficial effect of Mg intake on chronic diseases may be, at least in part, explained by inhibiting inflammation.
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