Plasma alkylresorcinols C17:0/C21:0 ratio, a biomarker of relative whole-grain rye intake, is associated to insulin sensitivity: a randomized study
Magnusdottir OK, Landberg R, Gunnarsdottir I, Cloetens L, Akesson B, Landin-Olsson M, Rosqvist F, Iggman D, Schwab U, Herzig KH, Savolainen MJ, Brader L, Hermansen K, Kolehmainen M, Poutanen K, Uusitupa M, Thorsdottir I, Risérus U
European journal of clinical nutrition · 21 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Biomarcadores de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Sveriges Lantbruksuniversitet
- Gobierno
- NordForsk
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-02-19 · Eur J Clin Nutr · vol. 68 · número 4 · págs. 453–458
- Editorial
- Springer Nature
- Citado
- 38 citas · más que el 94% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- alkylresorcinols, whole grain rye, whole wheat, metabolic syndrome, insulin sensitivity, glucose metabolism, Nordic diet, insulin secretion, Matsuda insulin sensitivity index, disposition index
- MeSH
- humans, triticum, insulin resistance, resorcinols, insulin, blood glucose, body mass index, linear models, dietary fiber, adult, aged, middle aged, healthy volunteers, biomarkers, secale, metabolic syndrome
18 autores
- Óla Kallý Magnúsdóttir🇮🇸 · autor de correspondenciaUniversity of Iceland; National University Hospital of Iceland
- Rikard Landberg🇸🇪Karolinska Institutet; Swedish University of Agricultural Sciences
- Ingibjörg Gunnarsdóttir🇮🇸University of Iceland; National University Hospital of Iceland
- Lieselotte Cloetens🇸🇪Lund University
- B Åkesson🇸🇪Lund University; Skåne University Hospital
- Mona Landin‐Olsson🇸🇪Skåne University Hospital
- Fredrik Rosqvist🇸🇪Uppsala University
- David Iggman🇸🇪Uppsala University; Center for Clinical Research Dalarna
- Ursula Schwab🇫🇮University of Eastern Finland; Kuopio University Hospital
- KH Herzig🇫🇮Kuopio University Hospital; University of Oulu
- Markku J. Savolainen🇫🇮Oulu University Hospital; University of Oulu
- Lea Brader🇩🇰Aarhus University Hospital
- Kjeld Hermansen🇩🇰Aarhus University Hospital
- Marjukka Kolehmainen🇫🇮University of Eastern Finland; VTT Technical Research Centre of Finland
- Kaisa S Poutanen🇫🇮University of Eastern Finland; VTT Technical Research Centre of Finland
- Matti Uusitupa🇫🇮University of Eastern Finland; Kuopio University Hospital
- Inga Þórsdóttir🇮🇸University of Iceland; National University Hospital of Iceland
- Ulf Risérus🇸🇪Uppsala University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/objectives
Few studies have used biomarkers of whole-grain intake to study its relation to glucose metabolism. We aimed to investigate the association between plasma alkylresorcinols (AR), a biomarker of whole-grain rye and wheat intake, and glucose metabolism in individuals with metabolic syndrome (MetS).
Subjects/methods
Participants were 30-65 years of age, with body mass index 27-40 kg/m(2) and had MetS without diabetes. Individuals were recruited through six centers in the Nordic countries and randomized to a healthy Nordic diet (ND, n=96), rich in whole-grain rye and wheat, or a control diet (n=70), for 18-24 weeks. In addition, associations between total plasma AR concentration and C17:0/C21:0 homolog ratio as an indication of the relative whole-grain rye intake, and glucose metabolism measures from oral glucose tolerance tests were investigated in pooled (ND+control) regression analyses at 18/24 weeks.
Results
ND did not improve glucose metabolism compared with control diet, but the AR C17:0/C21:0 ratio was inversely associated with fasting insulin concentrations (P=0.002) and positively associated with the insulin sensitivity indices Matsuda ISI (P=0.026) and disposition index (P=0.022) in pooled analyses at 18/24 weeks, even after adjustment for confounders. The AR C17:0/C21:0 ratio was not significantly associated with insulin secretion indices. Total plasma AR concentration was not related to fasting plasma glucose or fasting insulin at 18/24 weeks.
Conclusions
The AR C17:0/C21:0 ratio, an indicator of relative whole-grain rye intake, is associated with increased insulin sensitivity in a population with MetS.
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