Circulating omega-3 Fatty acids and neovascular age-related macular degeneration
Merle BM, Benlian P, Puche N, Bassols A, Delcourt C, Souied EH, Nutritional AMD Treatment 2 Study Group
Investigative ophthalmology & visual science · 82 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-02-20 · Invest Ophthalmol Vis Sci · vol. 55 · número 3 · pág. 2010
- Editorial
- Cadmus Press
- Citado
- 108 citas · más que el 97% de estudios similares · 7.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Retinal Diseases and Treatments · Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress
- Palabras clave
- neovascular age-related macular degeneration, omega-3 fatty acids, long-chain polyunsaturated fatty acids, eicosapentaenoic acid, docosahexaenoic acid, red blood cell membrane fatty acids, serum fatty acid composition, oily fish consumption
- MeSH
- humans, macular degeneration, retinal neovascularization, fatty acids, omega-3, fish oils, treatment outcome, chromatography, gas, retrospective studies, follow-up studies, double-blind method, aged, female, male, surveys and questionnaires
6 autores
- Bénédicte M. J. Merle🇫🇷Université Paris-Est Créteil; Hôpital Intercommunal de Créteil
- Pascale Benlian🇫🇷Université de Lille; Centre Hospitalier Universitaire de Lille
- Nathalie Puche🇫🇷Université Paris-Est Créteil; Hôpital Intercommunal de Créteil
- Ana Bassols
- Cécile Delcourt🇫🇷Université de Bordeaux; Inserm
- Eric H. Souied🇫🇷Université Paris-Est Créteil; Hôpital Intercommunal de Créteil
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
We assessed the associations of serum, red blood cell membranes (RBCM) and dietary long-chain n-3 polyunsaturated fatty acids (LC-PUFAs) with neovascular age-related macular degeneration (AMD).
Methods
We included 290 patients of the Nutritional AMD Treatment 2 Study (NAT2) with neovascular AMD in one eye and early AMD lesions in the other eye, and 144 normal vision controls without AMD. Dietary intake of seafood was estimated by food frequency questionnaire. Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) composition in serum and RBCM were determined by gas chromatography from 12-hour fasting blood samples and was expressed as percentages of total fatty acids profile. Logistic regressions estimated associations of neovascular AMD with dietary intake of seafood and circulating n-3 LC-PUFAs.
Results
Dietary oily fish and seafood intake were significantly lower in AMD patients than in controls. After adjustment for all potential confounders (age, sex, CFH Y402H, ARMS2 A69S, and ApoE4 polymorphisms, plasma triglycerides, hypertension, hypercholesterolemia, and family history of AMD), serum EPA was associated significantly with a lower risk for neovascular AMD (odds ratio [OR] = 0.41; 95% confidence interval [CI], 0.22-0.77; P = 0.005). Analysis of RBCM revealed that EPA and EPA+DHA were associated significantly with a lower risk for neovascular AMD (OR = 0.25; 95% CI, 0.13-0.47; P < 0.0001 and OR = 0.52; 95% CI, 0.29-0.94; P = 0.03, respectively).
Conclusions
The RBCM EPA and EPA+DHA, as long-term biomarkers of n-3 dietary PUFA status, were associated strongly with neovascular AMD and may represent an objective marker identifying subjects at high risk for neovascular AMD, who may most benefit from nutritional interventions. (http://www.controlled-trials.com/isrctn number, ISRCTN98246501).
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