Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet)
Lankinen M, Kolehmainen M, Jääskeläinen T, Paananen J, Joukamo L, Kangas AJ, Soininen P, Poutanen K, Mykkänen H, Gylling H, Orešič M, Jauhiainen M, Ala-Korpela M, Uusitupa M, Schwab U
PloS one · 54 citas
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Cómo se estudió
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- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- European Commission
- Gobierno
- Academy of Finland
- Gobierno
- Tekes
- Universidad u hospital
- Kuopion Yliopistollinen Sairaala
- Universidad u hospital
- Oulun Yliopisto
- Organización sin fines de lucro
- Diabetestutkimussäätiö
- Gobierno
- Medical Research Council
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- European Commission (FOOD-CT-2005-514008); Oulun Yliopisto (137870); European Commission (FOOD-CT-2005); Academy of Finland (137870); Academy of Finland (118590); Academy of Finland (131460); Academy of Finland (257545); Academy of Finland (070014); Tekes (070014)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-02-28 · PLoS One · vol. 9 · número 2 · pág. e90352
- Editorial
- Public Library of Science
- Citado
- 69 citas · más que el 97% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Phytoestrogen effects and research
- Palabras clave
- Postprandial, Lipid metabolism, Lipid profile, Food science, Blood lipids, Internal medicine, Polyunsaturated fatty acid, Lipoprotein, Cholesterol, Insulin, Metabolic syndrome, Endocrinology, Chemistry, Biology, Medicine, Fatty acid, Biochemistry, Obesity
- MeSH
- animals, humans, vaccinium myrtillus, fatty acids, omega-3, fatty acids, omega-6, apolipoproteins, diet, particle size, fish products, adult, aged, middle aged, female, male, lipid metabolism, cholesterol, hdl, metabolome, edible grain, metabolic syndrome
15 autores
- Maria Anneli Lankinen🇫🇮 · autor de correspondenciaUniversity of Eastern Finland
- Marjukka Kolehmainen🇫🇮University of Eastern Finland; VTT Technical Research Centre of Finland
- Tiina J. Jääskeläinen🇫🇮University of Eastern Finland
- Jussi Paananen🇫🇮University of Eastern Finland
- Laura Joukamo🇫🇮University of Eastern Finland
- Antti J. Kangas🇫🇮University of Oulu
- Pasi Soininen🇫🇮University of Eastern Finland; University of Oulu
- Kaisa S Poutanen🇫🇮University of Eastern Finland; VTT Technical Research Centre of Finland
- Hannu M Mykkänen🇫🇮University of Eastern Finland
- Helena Gylling🇫🇮University of Helsinki; University of Eastern Finland
- Matej Orešič🇫🇮VTT Technical Research Centre of Finland
- Matti Jauhiainen
- Mika Ala‐Korpela🇫🇮🇬🇧University of Eastern Finland; Oulu University Hospital; University of Bristol; Medical Research Council; University of Oulu
- Matti I.J. Uusitupa🇫🇮University of Eastern Finland; Kuopio University Hospital
- Ursula Schwab🇫🇮University of Eastern Finland; Kuopio University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome.
Methods
Altogether 131 subjects (40-70 y, BMI 26-39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites.
Results
There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable.
Conclusions
The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis.
Trial registration
The study was registered at ClinicalTrials.gov NCT00573781.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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