A whole-grain cereal-based diet lowers postprandial plasma insulin and triglyceride levels in individuals with metabolic syndrome
Giacco R, Costabile G, Della Pepa G, Anniballi G, Griffo E, Mangione A, Cipriano P, Viscovo D, Clemente G, Landberg R, Pacini G, Rivellese AA, Riccardi G
Nutrition, metabolism, and cardiovascular diseases : NMCD · 91 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
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- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- European Commission
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-01-28 · Nutr Metab Cardiovasc Dis · vol. 24 · número 8 · págs. 837–844
- Editorial
- Elsevier BV
- Citado
- 127 citas · más que el 99% de estudios similares · 9.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- whole grain cereals, refined grains, metabolic syndrome, postprandial insulin, triglycerides, postprandial blood glucose, lipid metabolism, dietary intervention, type 2 diabetes risk, cardiovascular disease
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, insulin, blood glucose, fatty acids, nonesterified, triglycerides, apolipoproteins a, apolipoproteins b, diet, nutrition assessment, linear models, patient compliance, glycemic index, postprandial period, adult, aged, middle aged, female, male, lipid metabolism, glucagon-like peptide 1, cholesterol, ldl, cholesterol, hdl, edible grain, metabolic syndrome
13 autores
- Rosalba Giacco🇮🇹 · autor de correspondenciaInstitute of Food Science; National Research Council
- Giuseppina Costabile🇮🇹Federico II University Hospital; University of Naples Federico II
- Giuseppe Della Pepa🇮🇹Federico II University Hospital; University of Naples Federico II
- Gaia Anniballi🇮🇹Federico II University Hospital; University of Naples Federico II
- Ettore Griffo🇮🇹Federico II University Hospital; University of Naples Federico II
- Anna Mangione🇮🇹Federico II University Hospital; University of Naples Federico II
- Paola Cipriano🇮🇹Federico II University Hospital; University of Naples Federico II
- D. Viscovo🇮🇹Federico II University Hospital; University of Naples Federico II
- Gennaro Clemente🇮🇹Institute of Food Science; National Research Council
- Rikard Landberg🇸🇪Swedish University of Agricultural Sciences
- Giovanni Pacini🇮🇹National Research Council
- Angela Albarosa Rivellese🇮🇹Federico II University Hospital; University of Naples Federico II
- Gabriele Riccardi🇮🇹Federico II University Hospital; University of Naples Federico II
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and aim
Until recently, very few intervention studies have investigated the effects of whole-grain cereals on postprandial glucose, insulin and lipid metabolism, and the existing studies have provided mixed results. The objective of this study was to evaluate the effects of a 12-week intervention with either a whole-grain-based or a refined cereal-based diet on postprandial glucose, insulin and lipid metabolism in individuals with metabolic syndrome.
Methods and results
Sixty-one men and women age range 40-65 years, with the metabolic syndrome were recruited to participate in this study using a parallel group design. After a 4-week run-in period, participants were randomly assigned to a 12-week diet based on whole-grain products (whole-grain group) or refined cereal products (control group). Blood samples were taken at the beginning and end of the intervention, both fasting and 3 h after a lunch, to measure biochemical parameters. Generalized linear model (GLM) was used for between-group comparisons. Overall, 26 participants in the control group and 28 in the whole-grain group completed the dietary intervention. Drop-outs (five in the control and two in the whole-grain group) did not affect randomization. After 12 weeks, postprandial insulin and triglyceride responses (evaluated as average change 2 and 3 h after the meal, respectively) decreased by 29% and 43%, respectively, in the whole-grain group compared to the run-in period. Postprandial insulin and triglyceride responses were significantly lower at the end of the intervention in the whole-grain group compared to the control group (p = 0.04 and p = 0.05; respectively) whereas there was no change in postprandial response of glucose and other parameters evaluated.
Conclusions
A twelve week whole-grain cereal-based diet, compared to refined cereals, reduced postprandial insulin and triglycerides responses. This finding may have implications for type 2 diabetes risk and cardiovascular disease.
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