Omega-3 fatty acids in the prevention of interferon-alpha-induced depression: results from a randomized, controlled trial
Su KP, Lai HC, Yang HT, Su WP, Peng CY, Chang JP, Chang HC, Pariante CM
Biological psychiatry · 164 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Gobierno
- National Science Council
- Gobierno
- Medical Research Council
- Universidad u hospital
- China Medical University in Taiwan
- Gobierno
- National Health Research Institute
- Subvenciones
- National Science Council (102-2911-I-039-501); National Science Council (101-2320-B-038-020-MY2); National Institute for Health and Care Research (NHRI-EX101-10144NI); National Science Council (101-2628-B-039-001-MY3); Medical Research Council (MR/J002739/1)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2014-01-24 · Biol Psychiatry · vol. 76 · número 7 · págs. 559–566
- Editorial
- Elsevier BV
- Citado
- 204 citas · más que el 100% de estudios similares · 17.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 87 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Fatty Acid Research and Health · Tryptophan and brain disorders · Treatment of Major Depression
- Palabras clave
- omega-3 fatty acids, chronic hepatitis C, eicosapentaenoic acid, docosahexaenoic acid, depression prevention, inflammation and depression
- MeSH
- humans, hepatitis c, docosahexaenoic acids, eicosapentaenoic acid, interferon-alpha, double-blind method, depression, middle aged, female, male
8 autores
- Kuan‐Pin Su🇬🇧🇹🇼🇨🇳King's College London; China Medical University; China Medical University Hospital; China Medical University
- Hsueh‐Chou Lai🇹🇼China Medical University; China Medical University Hospital
- Hui-Ting Yang🇹🇼China Medical University
- Wen‐Pang Su🇹🇼China Medical University; China Medical University Hospital
- Cheng‐Yuan Peng🇹🇼China Medical University; China Medical University Hospital
- Jane Pei‐Chen Chang🇹🇼China Medical University; China Medical University Hospital
- Hui-Chih Chang🇬🇧🇹🇼🇨🇳King's College London; China Medical University; China Medical University Hospital; Taipei Medical University; China Medical University
- Carmine Maria Pariante🇬🇧 · autor de correspondenciaKing's College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Interferon (IFN)-α therapy for chronic hepatitis C virus infection is frequently associated with depression. The routine prophylaxis with antidepressants might expose patients to adverse effects, hence, the need for alternative preventive interventions. Omega-3 polyunsaturated fatty acids are safe and effective essential nutritional compounds used for the treatment of depression, putatively through an anti-inflammatory action. In addition, lower erythrocyte levels of omega-3 polyunsaturated fatty acids have been associated with an increased risk of IFN-induced depression.
Methods
We conducted a 2-week, double-blind, placebo-controlled trial comparing eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and placebo for the prevention of IFN-α-induced depression. A total of 162 patients consented to participate and were randomized to the study. All of the patients completed the 2-week trial; 152 participants were followed throughout the 24 weeks of IFN-α treatment and were included in the analysis.
Results
Compared with placebo, the incident rates of IFN-α-induced depression were significantly lower in EPA-treated but not in DHA-treated patients (10% and 28%, respectively, versus 30% for placebo, p = .037). Both EPA and DHA significantly delayed the onset of IFN-induced depression (week of onset: 12.0 and 11.7, respectively, versus 5.3 for placebo, p = .002). EPA and DHA were both well tolerated in this population. EPA treatment increased both EPA and DHA erythrocyte levels, but DHA only increased DHA erythrocyte levels.
Conclusions
EPA is effective in the prevention of depression in hepatitis C virus patients received IFN-α therapy. Our study confirms the notion that anti-inflammatory strategies are effective antidepressants in the context of depression associated with inflammation.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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