Vitamin D and pre-eclampsia: original data, systematic review and meta-analysis
Hyppönen E, Cavadino A, Williams D, Fraser A, Vereczkey A, Fraser WD, Bánhidy F, Lawlor D, Czeizel AE
Annals of nutrition & metabolism · 121 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- British Heart Foundation
- Universidad u hospital
- University College London
- Universidad u hospital
- University of Bristol
- Gobierno
- Academy of Finland
- Universidad u hospital
- Great Ormond Street Hospital for Children
- Gobierno
- Medical Research Council
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- Medical Research Council (G0701603); University of Bristol (G0701603); Medical Research Council (G0601653); National Institute for Health and Care Research (PHCS/C4/4/016); Wellcome Trust (WT076467); Wellcome Trust (G0600705); British Heart Foundation (PG/09/023/26806); University of Bristol (G0600705); Wellcome Trust (G0701603); British Heart Foundation (G0600705); Medical Research Council (G0600705)
Según 9 financiadores declarados.
Publicación
- Publicado
- 2013-01-01 · Ann Nutr Metab · vol. 63 · número 4 · págs. 331–340
- Editorial
- Karger Publishers
- Citado
- 188 citas · más que el 95% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 51 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Pregnancy and preeclampsia studies · Vitamin D Research Studies · Birth, Development, and Health
- Palabras clave
- vitamin D, preeclampsia, vitamin D supplementation, 25-hydroxyvitamin D, pregnancy, preeclampsia prevention, Avon Longitudinal Study of Parents and Children
- MeSH
- humans, pre-eclampsia, vitamin d, risk factors, nutritional status, pregnancy, dietary supplements, female, randomized controlled trials as topic, observational studies as topic
9 autores
- Elina Hyppönen🇦🇺🇬🇧University of South Australia; South Australian Health and Medical Research Institute; University College London
- Alana Cavadino🇬🇧University College London
- David J. Williams🇬🇧University College Hospital; University College London
- Abigail Fraser🇬🇧University of Bristol
- Attila Vereczkey
- William Duncan Fraser🇬🇧University of East Anglia
- Ferenc G. Bánhidy🇭🇺Semmelweis University
- Debbie A. Lawlor🇬🇧University of Bristol
- Andrew E. Czeizel
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background/aims
Vitamin D may protect from pre-eclampsia through influences on immune modulation and vascular function. To evaluate the role of vitamin D in the development of pre-eclampsia, we conducted a systematic review and meta-analysis including novel data from 2 large-scale epidemiological studies.
Methods
PubMed, EMBASE and the Cochrane Central Register of Controlled Trials were searched for prospective observational studies of association between vitamin D supplementation or status (measured by maternal 25-hydroxyvitamin D, 25(OH)D) with a subsequent risk of pre-eclampsia, or randomised controlled trials using vitamin D supplementation to prevent pre-eclampsia. The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA) and the Avon Longitudinal Study of Parents and Children (ALSPAC) were included in meta-analyses with published studies.
Results
Mothers receiving vitamin D supplementation earlier in pregnancy had lower odds of pre-eclampsia [pooled odds ratios (OR) 0.81 and 95% confidence interval (CI) 0.75-0.87, p = 2.4 × 10(-8), 2 studies] in the meta-analysis of published studies with HCCSCA. The meta-analysis of published studies with ALSPAC suggested an association between higher serum 25(OH)D levels and a reduced risk of pre-eclampsia (pooled OR 0.52 and 95% CI 0.30-0.89, p = 0.02, 6 studies). Randomised trials of supplementation were suggestive of protective association (pooled OR 0.66 and 95% CI 0.52-0.83, p = 0.001, 4 studies).
Conclusions
This study suggests that low maternal serum 25(OH)D concentrations increase pre-eclampsia risk and that vitamin D supplementation lowers this risk. The quality of evidence is insufficient to determine a causal association, which highlights the need for adequately powered clinical trials.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.