Vitamin D supplementation for depressive symptoms: a systematic review and meta-analysis of randomized controlled trials
Shaffer JA, Edmondson D, Wasson LT, Falzon L, Homma K, Ezeokoli N, Li P, Davidson KW
Psychosomatic medicine · 172 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01HL117832); National Heart, Lung, and Blood Institute (HL088117); National Heart, Lung, and Blood Institute (K23HL112850); National Heart, Lung, and Blood Institute (HL117832); National Heart, Lung, and Blood Institute (HL114924); National Heart, Lung, and Blood Institute (HL-084034); National Heart, Lung, and Blood Institute (K24HL084034); National Heart, Lung, and Blood Institute (P01HL088117); National Heart, Lung, and Blood Institute (T32HL007343)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-03-15 · Psychosom Med · vol. 76 · número 3 · págs. 190–196
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 227 citas · más que el 99% de estudios similares · 15.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Treatment of Major Depression · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, depressive symptoms, depression, antidepressant effects, vitamin D deficiency
- MeSH
- humans, vitamins, vitamin d, antidepressive agents, treatment outcome, data interpretation, statistical, depression, depressive disorder, dietary supplements, randomized controlled trials as topic
8 autores
- Jonathan A. Shaffer🇺🇸 · autor de correspondenciaFlorida State University; Columbia University Irving Medical Center; New York University; Stanford University
- Donald E. Edmondson🇺🇸Columbia University Irving Medical Center; New York University; Columbia University; Stanford University
- Lauren Taggart Wasson🇺🇸Columbia University Irving Medical Center; New York University; Columbia University; Stanford University
- Louise Falzon🇺🇸Columbia University Irving Medical Center; New York University; Columbia University; Stanford University
- Kirsten Homma🇺🇸Columbia University Irving Medical Center; New York University; Columbia University; Stanford University
- Nchedcochukwu Ezeokoli🇺🇸Columbia University Irving Medical Center; New York University; Columbia University; Stanford University
- Peter Chi-Win Li🇺🇸Columbia University Irving Medical Center; New York University; Columbia University; Stanford University
- Karina W. Davidson🇺🇸Columbia University Irving Medical Center; New York University; Columbia University; Stanford University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The aim of this study was to review the effects of vitamin D supplementation on depressive symptoms in randomized controlled trials. Although low vitamin D levels have been observationally associated with depressive symptoms, the effect of vitamin D supplementation as an antidepressant remains uncertain.
Methods
MEDLINE, CINAHL, AMED, PsycINFO, Scopus, The Cochrane Library, and references of included reports (through May 2013) were searched. Two independent reviewers identified and extracted data from randomized trials that compared the effect of vitamin D supplementation on depressive symptoms to a control condition. Two additional reviewers assessed study quality using The Cochrane Risk of Bias Tool. Seven trials (3191 participants) were included.
Results
Vitamin D supplementation had no overall effect on depressive symptoms (standardized mean difference [SMD], 0.14; 95% confidence interval [CI], -0.33 to 0.05, p = .16), although considerable heterogeneity was observed. Subgroup analysis showed that vitamin D supplementation for participants with clinically significant depressive symptoms or depressive disorder had a moderate, statistically significant effect (2 studies: SMD, -0.60; 95% CI, -1.19 to -0.01; p = .046), but a small, nonsignificant effect for those without clinically significant depression (5 studies: SMD, -0.04; 95% CI, -0.20 to 0.12; p = .61). Most trials had unclear or high risk of bias. Studies varied in the amount, frequency, duration, and mode of delivery of vitamin D supplementation.
Conclusions
Vitamin D supplementation may be effective for reducing depressive symptoms in patients with clinically significant depression; however, further high-quality research is needed.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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