Obstetric and neonatal outcomes of maternal vitamin D supplementation: results of an open-label, randomized controlled trial of antenatal vitamin D supplementation in Pakistani women
Hossain N, Kanani FH, Ramzan S, Kausar R, Ayaz S, Khanani R, Pal L
The Journal of clinical endocrinology and metabolism · 106 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-03-19 · J Clin Endocrinol Metab · vol. 99 · número 7 · págs. 2448–2455
- Editorial
- Oxford University Press
- Citado
- 153 citas · más que el 99% de estudios similares · 12.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Maternal and Perinatal Health Interventions
- Palabras clave
- vitamin D supplementation, 25-hydroxyvitamin D, maternal vitamin D status, neonatal vitamin D status, umbilical cord blood, obstetric outcomes, neonatal outcomes, gestational hypertension, gestational diabetes mellitus, preterm labor, Apgar score, small for gestational age, birth weight, Pakistani women, vitamin D deficiency in pregnancy
- MeSH
- humans, pregnancy complications, infant, newborn, diseases, vitamin d deficiency, vitamin d, pregnancy outcome, prenatal care, delivery, obstetric, pregnancy, dietary supplements, adult, infant, newborn, pakistan, female, maternal nutritional physiological phenomena, young adult
7 autores
- Nazli Hossain · autor de correspondencia
- Fatima Husain Kanani🇵🇰Dow University of Health Sciences
- Shabana Ramzan
- Robina Kausar🇵🇰Dow University of Health Sciences
- Shabana Ayaz
- Rafiq Khanani
- Lubna Pal🇺🇸Yale University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The objective of the study was to determine whether vitamin D (vitD) supplementation during pregnancy affects obstetric and neonatal outcomes.
Setting
The study was conducted at a university hospital in Karachi, Pakistan.
Methods
The study was a single-center, open-label, randomized, controlled trial of routine care (group A, 200 mg ferrous sulfate and 600 mg calcium daily) vs vitD supplementation (group B, 4000 IU vitamin D3 daily), started at 20 weeks and continued till delivery. Maternal serum samples of 25-hydroxyvitamin D (25OHD) were collected at baseline and delivery. Neonatal vitD status was assessed in cord blood or in neonatal serum samples within 48 hours of birth. Obstetric outcomes included gestational hypertension, gestational diabetes, and preterm labor, and neonatal well-being included small for gestational age, birth weight, length, head circumference, and 1- and 5-minute Apgar scores.
Results
Of 207 gravidae enrolled, 193 completed the trial. Maternal age, vitD status, and gestational age at enrollment were comparable between the two groups. At delivery, maternal 25OHD was increased in group B (18.3 ± 11 ng/dL vs 8.82 ± 11.84 ng/dL (P = .001) compared with group A (6.9 ± 7.0 ng/dL vs 6.32 ± 3.97 ng/dL, P = .06). The obstetric outcomes were comparable between the two groups (P > .05). Neonatal 25OHD levels were significantly higher in group B compared with group A (19.22 ± 12.19 ng/dL vs 6.27 ± 5.2 ng/dL). There was positive correlation between maternal and neonatal 25OHD levels (r = 0.83, P = .001). One- and 5-minute Apgar scores were significantly higher in group B (7.10 ± 0.66 vs 6.90 ± 0.50, P = .026, and 8.53 ± 0.68 vs 8.33 ± 0.81, P = .051, respectively). Neonatal anthropometric parameters were comparable between the two groups (P > .05).
Conclusion
Maternal vitD supplementation improved maternal and neonatal vitD status.
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