Caffeine intake and atrial fibrillation incidence: dose response meta-analysis of prospective cohort studies
Cheng M, Hu Z, Lu X, Huang J, Gu D
The Canadian journal of cardiology · 76 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-01-03 · Can J Cardiol · vol. 30 · número 4 · págs. 448–454
- Editorial
- Elsevier BV
- Citado
- 107 citas · más que el 81% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Atrial Fibrillation Management and Outcomes · Nutritional Studies and Diet
- Palabras clave
- caffeine consumption, atrial fibrillation, dose-response relationship, coffee consumption, cardiovascular risk
- MeSH
- humans, atrial fibrillation, caffeine, central nervous system stimulants, incidence, prospective studies, dose-response relationship, drug
5 autores
- Min Cheng🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Zunsong Hu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Xiangfeng Lu🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Jianfeng Huang🇨🇳Chinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
- Dongfeng Gu🇨🇳 · autor de correspondenciaChinese Academy of Medical Sciences & Peking Union Medical College; Fu Wai Hospital; State Key Laboratory of Cardiovascular Disease
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The association between habitual caffeine intake with incident atrial fibrillation (AF) was unknown. We conducted a meta-analysis to investigate the association between chronic exposure of caffeine and the risk of AF and to evaluate the potential dose-response relation.
Methods
We searched PubMed, EMBASE, and the Cochrane Library up to November 2013 and references of relevant retrieved articles. Prospective cohort studies were included with relative risk (RR) or hazard ratio and 95% confidence intervals (CIs) for AF according to coffee/caffeine intake.
Results
Six prospective cohort studies with 228,465 participants were included. In the primary meta-analysis, caffeine exposure was weakly associated with a reduced risk of AF (RR, 0.90; 95% CI, 0.81-1.01; P = 0.07; I(2) = 73%). In subgroup analyses, pooled results from studies with adjustment of potential confounders showed an 11% reduction for low doses (RR, 0.89; 95% CI, 0.80-0.99, P = 0.032; I(2) = 30.9%, P = 0.227) and 16% for high doses (RR, 0.84; 95% CI, 0.75-0.94, P = 0.002; I(2) = 24.1%, P = 0.267) of caffeine consumption in AF risk. An inverse relation was found between habitual caffeine intake and AF risk (P for overall trend = 0.015; P for nonlinearity = 0.27) in dose-response meta-analysis and the incidence of AF decreased by 6% (RR, 0.94; 95% CI, 0.90-0.99) for every 300 mg/d increment in habitual caffeine intake.
Conclusions
It is unlikely that caffeine consumption causes or contributes to AF. Habitual caffeine consumption might reduce AF risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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