Red meat consumption and stomach cancer risk: a meta-analysis
Song P, Lu M, Yin Q, Wu L, Zhang D, Fu B, Wang B, Zhao Q
Journal of cancer research and clinical oncology · 37 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Nanjing University
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-03-28 · J Cancer Res Clin Oncol · vol. 140 · número 6 · págs. 979–992
- Editorial
- Springer Science+Business Media
- Citado
- 58 citas · más que el 78% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Nutritional Studies and Diet · Gastric Cancer Management and Outcomes · Helicobacter pylori-related gastroenterology studies
- Palabras clave
- red meat consumption, gastric cancer, gastric cancer risk, dietary risk factors, dose-response relationship, case-control study, cohort studies, study design heterogeneity
- MeSH
- humans, stomach neoplasms, prognosis, diet, risk factors, case-control studies, meat
8 autores
- Peng Kun Song🇨🇳Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Ming Lu🇨🇳Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Qin Yin🇨🇳Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Lei Wu🇨🇳Jiangsu Province Hospital
- Dong Zhang🇨🇳Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Bo Fu🇨🇳Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Baolin Wang🇨🇳Second Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
- Qinghong Zhao🇨🇳 · autor de correspondenciaSecond Affiliated Hospital of Nanjing Medical University; Nanjing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The association of red meat consumption with the risk of stomach cancer has been reported by many studies, with inconclusive results. We performed a meta-analysis of cohort and case-control studies to provide a quantitative assessment of this association.
Methods
Relevant studies were identified by searching PubMed and Embase before December 2013 without restrictions. A total of 18 studies involving 1,228,327 subjects were included in this meta-analysis. Summary relative risks were estimated using random effects models.
Results
The pooled relative risks of gastric cancer were 1.37 (95 % CI 1.18-1.59) for the highest versus lowest categories of red meat intake with significant heterogeneity among studies (P(heterogeneity) < 0.001, I(2) = 67.6 %). When stratified by the study design, the significant associations were observed in population-based case-control studies (RR 1.58; 95 % CI 1.22-2.06; P(heterogeneity) < 0.001, I(2) = 73.0 %) and hospital-based case-control studies (RR 1.63; 95 % CI 1.38-1.92; P(heterogeneity) = 0.284, I(2) = 19.1 %). However, no association was observed among cohort studies (RR 1.00; 95 % CI 0.83-1.20; P(heterogeneity) = 0.158, I(2) = 33.9 %). The significant association was also presented in the subgroup analysis by geographic area (Asia, Europe), publication year (≥2000), sample size (<1,000, ≥1,000) and quality score (<7 stars, ≥7 stars). The dose-response analysis associated every 100 g/day increment in red meat intake with a 17 % increased gastric cancer risk (RR 1.17; 95 % CI 1.05-1.32). A linear regression model further revealed that the risk of gastric cancer increased with increasing level of red meat consumption.
Conclusions
Increased intake of red meat might be a risk factor for stomach cancer. Further larger prospective studies are warranted to verify this association.
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