Financiado en parte por Nestec
Vitamin D and risk of cause specific death: systematic review and meta-analysis of observational cohort and randomised intervention studies
Chowdhury R, Kunutsor S, Vitezova A, Oliver-Williams C, Chowdhury S, Kiefte-de-Jong JC, Khan H, Baena CP, Prabhakaran D, Hoshen MB, Feldman BS, Pan A, Johnson L, Crowe F, Hu FB, Franco OH
BMJ (Clinical research ed.) · 426 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Nestec
- Gobierno
- Medical Research Council
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-04-01 · BMJ · vol. 348 · número apr01 2 · pág. g1903
- Citado
- 631 citas · más que el 100% de estudios similares · 13.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 84 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Nutrition and Health Studies
- Palabras clave
- vitamin D, 25-hydroxyvitamin D, vitamin D supplementation, vitamin D3, vitamin D2, cause-specific mortality, cardiovascular mortality, cancer mortality, all-cause mortality, primary prevention, secondary prevention, vitamin D deficiency
- MeSH
- humans, vitamin d deficiency, vitamins, vitamin d, cause of death, risk factors, dietary supplements
16 autores
- Rajiv Chowdhury🇬🇧 · autor de correspondenciaUniversity of Cambridge
- Setor Kwadzo Kunutsor🇬🇧University of Cambridge
- Anna Vitezova🇳🇱Erasmus MC
- Clare Oliver‐Williams🇬🇧University of Cambridge
- S. Chowdhury
- Jessica C. Kiefte–de Jong🇳🇱Erasmus MC
- Hassan Khan🇬🇧University of Cambridge
- Cristina Pellegrino Baena🇧🇷Pontifícia Universidade Católica do Paraná
- Dorairaj Prabhakaran🇮🇳Centre for Chronic Disease Control
- Moshe B Hoshen🇮🇱Clalit Health Services
- Becca Feldman🇮🇱Clalit Health Services
- An Pan🇺🇸🇸🇬Harvard University; National University of Singapore
- Laura Johnson🇬🇧University of Bristol
- Francesca L. Crowe🇬🇧University of Oxford
- Frank B. Hu🇺🇸Harvard University
- Oscar H. Franco🇳🇱 · autor de correspondenciaErasmus MC
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances.
Design
Systematic review and meta-analysis of observational studies and randomised controlled trials.
Data sources
Medline, Embase, Cochrane Library, and reference lists of relevant studies to August 2013; correspondance with investigators.
Study selection
Observational cohort studies and randomised controlled trials in adults, which reported associations between vitamin D (measured as circulating 25-hydroxyvitamin D concentration or vitamin D supplement given singly) and cause specific mortality outcomes.
Data extraction
Data were extracted by two independent investigators, and a consensus was reached with involvement of a third. Study specific relative risks from 73 cohort studies (849,412 participants) and 22 randomised controlled trials (vitamin D given alone versus placebo or no treatment; 30,716 participants) were meta-analysed using random effects models and were grouped by study and population characteristics.
Results
In the primary prevention observational studies, comparing bottom versus top thirds of baseline circulating 25-hydroxyvitamin D distribution, pooled relative risks were 1.35 (95% confidence interval 1.13 to 1.61) for death from cardiovascular disease, 1.14 (1.01 to 1.29) for death from cancer, 1.30 (1.07 to 1.59) for non-vascular, non-cancer death, and 1.35 (1.22 to 1.49) for all cause mortality. Subgroup analyses in the observational studies indicated that risk of mortality was significantly higher in studies with lower baseline use of vitamin D supplements. In randomised controlled trials, relative risks for all cause mortality were 0.89 (0.80 to 0.99) for vitamin D3 supplementation and 1.04 (0.97 to 1.11) for vitamin D2 supplementation. The effects observed for vitamin D3 supplementation remained unchanged when grouped by various characteristics. However, for vitamin D2 supplementation, increased risks of mortality were observed in studies with lower intervention doses and shorter average intervention periods.
Conclusions
Evidence from observational studies indicates inverse associations of circulating 25-hydroxyvitamin D with risks of death due to cardiovascular disease, cancer, and other causes. Supplementation with vitamin D3 significantly reduces overall mortality among older adults; however, before any widespread supplementation, further investigations will be required to establish the optimal dose and duration and whether vitamin D3 and D2 have different effects on mortality risk.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.