Self-reported whole-grain intake and plasma alkylresorcinol concentrations in combination in relation to the incidence of colorectal cancer
Knudsen MD, Kyrø C, Olsen A, Dragsted LO, Skeie G, Lund E, Aman P, Nilsson LM, Bueno-de-Mesquita HB, Tjønneland A, Landberg R
American journal of epidemiology · 25 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de casos y controles (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universitetet i Tromsø
- Organización sin fines de lucro
- World Cancer Research Fund International
- Universidad u hospital
- Imperial College London
- Universidad u hospital
- Karolinska Institutet
- Universidad u hospital
- Umeå Universitet
- Organización sin fines de lucro
- World Cancer Research Fund
- Universidad u hospital
- School of Public Health, Imperial College London
Según 7 financiadores declarados.
Publicación
- Publicado
- 2014-04-03 · Am J Epidemiol · vol. 179 · número 10 · págs. 1188–1196
- Editorial
- Oxford University Press
- Citado
- 44 citas · más que el 97% de estudios similares · 7.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Liver Disease Diagnosis and Treatment · Diet and metabolism studies
- Palabras clave
- Colorectal cancer, Incidence (geometry), Medicine, Whole grains, Internal medicine, Oncology, Cancer, Gastroenterology, Endocrinology, Physiology, Food science, Chemistry, Mathematics
- MeSH
- humans, colorectal neoplasms, resorcinols, diet, health behavior, life style, adult, middle aged, educational status, female, male, biomarkers, surveys and questionnaires, edible grain
11 autores
- Markus Dines Knudsen🇩🇰Danish Cancer Society
- Cecilie Kyrø🇩🇰 · autor de correspondenciaDanish Cancer Society
- Anja Olsen🇩🇰Danish Cancer Society
- Lars Ove Dragsted🇩🇰🇧🇪University of Copenhagen; Nutrition Sciences (Belgium); Danish Cancer Society
- Guri Skeie🇳🇴🇩🇰Centre for Arctic Gas Hydrate, Environment and Climate; Danish Cancer Society; UiT The Arctic University of Norway
- Eiliv Lund🇳🇴🇩🇰Centre for Arctic Gas Hydrate, Environment and Climate; Danish Cancer Society; UiT The Arctic University of Norway
- Per Åman🇵🇰University of Agriculture Faisalabad
- Lena Maria Nilsson🇩🇰🇸🇪Danish Cancer Society; Umeå University
- H. Bas Bueno‐de‐Mesquita🇳🇱🇩🇰National Institute for Public Health and the Environment; Danish Cancer Society
- Anne Marie Tjønneland🇩🇰Danish Cancer Society
- Rikard Landberg🇩🇰🇵🇰Danish Cancer Society; University of Agriculture Faisalabad
Resumen
El texto original del estudio, en el idioma en que se publicó.
Self-reported food frequency questionnaires (FFQs) have occasionally been used to investigate the association between whole-grain intake and the incidence of colorectal cancer, but the results from those studies have been inconsistent. We investigated this association using intakes of whole grains and whole-grain products measured via FFQs and plasma alkylresorcinol concentrations, a biomarker of whole-grain wheat and rye intake, both separately and in combination (Howe's score with ranks). We conducted a nested case-control study in a cohort from a research project on Nordic health and whole-grain consumption (HELGA, 1992-1998). Incidence rate ratios and 95% confidence intervals were calculated using conditional logistic regression. Plasma alkylresorcinol concentrations alone and Howe's score with ranks were inversely associated with the incidence of distal colon cancer when the highest quartile was compared with the lowest (for alkylresorcinol concentrations, incidence rate ratio = 0.34, 95% confidence interval: 0.13, 0.92; for Howe's score with ranks, incidence rate ratio = 0.35, 95% confidence interval: 0.15, 0.86). No association was observed between whole-grain intake and any colorectal cancer (colon, proximal, distal or rectum cancer) when using an FFQ as the measure/exposure variable for whole-grain intake. The results suggest that assessing whole-grain intake using a combination of FFQs and biomarkers slightly increases the precision in estimating the risk of colon or rectal cancer by reducing the impact of misclassification, thereby increasing the statistical power of the study.
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