Does increased water intake prevent disease progression in autosomal dominant polycystic kidney disease?
Higashihara E, Nutahara K, Tanbo M, Hara H, Miyazaki I, Kobayashi K, Nitatori T
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 42 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-04-15 · Nephrol Dial Transplant · vol. 29 · número 9 · págs. 1710–1719
- Editorial
- Oxford University Press
- Citado
- 63 citas · más que el 96% de estudios similares · 5.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Genetic and Kidney Cyst Diseases · Renal Diseases and Glomerulopathies · Ion Transport and Channel Regulation
- Palabras clave
- Medicine, Autosomal dominant polycystic kidney disease, Kidney disease, Disease, Polycystic kidney disease, Internal medicine, Endocrinology, Physiology
- MeSH
- kidney, humans, polycystic kidney, autosomal dominant, disease progression, glycopeptides, glomerular filtration rate, organ size, blood pressure, drinking, adult, middle aged, female, male, young adult
7 autores
- Eiji Higashihara🇯🇵 · autor de correspondenciaKyorin University
- Kikuo Nutahara🇯🇵Kyorin University
- Mitsuhiro Tanbo🇯🇵Kyorin University
- Hidehiko Hara🇯🇵Kyorin University
- Isao Miyazaki🇯🇵Kyorin University
- Kuninori Kobayashi🇯🇵Kyorin University
- Toshiaki Nitatori🇯🇵Kyorin University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The clinical effects of increased water intake on autosomal dominant polycystic kidney disease (ADPKD) progression are unknown.
Methods
ADPKD patients with creatinine clearance ≧ 50 mL/min/1.73 m(2) were divided into high (H-, n = 18) and free (F-, n = 16) water-intake groups, mainly according to their preference. Prior to the study, 30 patients underwent annual evaluation of total kidney volume (TKV) and 24-h urine for an average of 33 months. During the 1-year study period, TKV and 24-h urine were analyzed at the beginning and end of the study and every 4 months, respectively.
Results
During the pre-study period, urine volume (UV) in the H-group was higher (P = 0.034), but TKV and kidney function and their slopes were not significantly different between the two groups. After the study commenced, UV further increased (P < 0.001) in the H-group but not in the F-group. During the study period, TKV and kidney function slopes were not significantly different between the two groups (primary endpoint). Plasma copeptin was lower (P = 0.024) in the H-group than in the F-group. TKV and kidney function slopes became worse (P = 0.047 and 0.011, respectively) after high water intake (H-group) but not in the F-group. High UV was associated with increased urine sodium, and urine sodium positively correlated with the % TKV slope (P = 0.014).
Conclusions
Although the main endpoint was not significant, high water intake enhanced disease progression in the H-group when compared with the pre-study period. These findings necessitate a long-term randomized study before drawing a final conclusion.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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