Financiado en parte por Western Grains Research Foundation, Canola Council of Canada
Plasma fatty acid changes following consumption of dietary oils containing n-3, n-6, and n-9 fatty acids at different proportions: preliminary findings of the Canola Oil Multicenter Intervention Trial (COMIT)
Senanayake VK, Pu S, Jenkins DA, Lamarche B, Kris-Etherton PM, West SG, Fleming JA, Liu X, McCrea CE, Jones PJ
Trials · 32 citas
Etiquetas de revisión
Vínculos de autores con la industriaAlimentación controladaFinanciado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiado por la industria
- Grupo de la industria
- Western Grains Research Foundation
- Grupo de la industria
- Canola Council of Canada
- Gobierno
- Canada Research Chairs
- Gobierno
- National Institutes of Health
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- Agriculture and Agri-Food Canada
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- CIHR
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR000127); National Center for Advancing Translational Sciences (TR000127); National Center for Research Resources (UL1 RR033184); National Institutes of Health (1ul1rr033184-01); National Center for Research Resources (UL1 TR000127); National Center for Research Resources (RR033184); National Center for Advancing Translational Sciences (RR033184); National Institutes of Health (TR000127); National Institutes of Health (UL1-TR-000127)
Según 11 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-04-23 · Trials · vol. 15 · número 1 · pág. 136
- Editorial
- Springer Science+Business Media
- Citado
- 39 citas · más que el 95% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Nutritional Studies and Diet
- Palabras clave
- plasma fatty acid profile, edible oils, omega-3 fatty acids, omega-6 fatty acids, n-9 fatty acids, canola oil, docosahexaenoic acid, linseed oil, safflower oil, corn oil, abdominal obesity, cardiovascular risk factors, dietary adherence, recruitment and retention
- MeSH
- humans, cardiovascular diseases, blood glucose, lipids, corn oil, docosahexaenoic acids, safflower oil, linseed oil, fatty acids, monounsaturated, oleic acid, fatty acids, omega-6, treatment outcome, diet, cross-over studies, patient compliance, blood pressure, time factors, adult, middle aged, patient dropouts, canada, pennsylvania, female, male, waist circumference, obesity, abdominal, biomarkers, rapeseed oil
10 autores
- Vijitha K. Senanayake🇨🇦University of Manitoba
- Shuaihua Pu🇨🇦University of Manitoba
- David A Jenkins🇨🇦St. Michael's Hospital
- Benoı̂t Lamarche🇨🇦Université Laval; Institut sur la nutrition et les aliments fonctionnels (INAF)
- Penny M. Kris‐Etherton🇺🇸Pennsylvania State University
- Sheila G. West🇺🇸Pennsylvania State University
- Jennifer A Fleming🇺🇸Pennsylvania State University
- Xiaoran Liu🇺🇸Pennsylvania State University
- Cindy E McCrea🇺🇸Pennsylvania State University
- Peter J.H. Jones🇨🇦 · autor de correspondenciaUniversity of Manitoba
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The Canola Oil Multicenter Intervention Trial (COMIT) was a randomized controlled crossover study designed to evaluate the effects of five diets that provided different oils and/or oil blends on cardiovascular disease (CVD) risk factors in individuals with abdominal obesity. The present objective is to report preliminary findings on plasma fatty acid profiles in volunteers with abdominal obesity, following the consumption of diets enriched with n-3, n-6 and n-9 fatty acids.
Methods
COMIT was conducted at three clinical sites, Winnipeg, Manitoba, Canada, Québec City, Québec, Canada and University Park, Pennsylvania, United States. Inclusion criteria were at least one of the followings: waist circumference (≥90 cm for males and ≥84 cm for females), and at least one other criterion: triglycerides ≥1.7 mmol/L, high density lipoprotein cholesterol <1 mmol/L (males) or <1.3 mmol/L (females), blood pressure ≥130 mmHg (systolic) and/or ≥85 mmHg (diastolic), and glucose ≥5.5 mmol/L. Weight-maintaining diets that included shakes with one of the dietary oil blends were provided during each of the five 30-day dietary phases. Dietary phases were separated by four-week washout periods. Treatment oils were canola oil, high oleic canola oil, high oleic canola oil enriched with docosahexaenoic acid (DHA), flax oil and safflower oil blend, and corn oil and safflower oil blend. A per protocol approach with a mixed model analysis was decided to be appropriate for data analysis.
Results
One hundred and seventy volunteers were randomized and 130 completed the study with a dropout rate of 23.5%. The mean plasma total DHA concentrations, which were analyzed among all participants as a measure of adherence, increased by more than 100% in the DHA-enriched phase, compared to other phases, demonstrating excellent dietary adherence.
Conclusions
Recruitment and retention strategies were effective in achieving a sufficient number of participants who completed the study protocol to enable sufficient statistical power to resolve small differences in outcome measures. It is expected that the study will generate important data thereby enhancing our understanding of the effects of n-3, n-6, and n-9 fatty acid-containing oils on CVD risks.
Trial registration
ClinicalTrials.gov NCT01351012.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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