Vitamin D supplementation and falls: a trial sequential meta-analysis
Bolland MJ, Grey A, Gamble GD, Reid IR
The lancet. Diabetes & endocrinology · 98 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-04-23 · Lancet Diabetes Endocrinol · vol. 2 · número 7 · págs. 573–580
- Editorial
- Elsevier BV
- Citado
- 158 citas · más que el 100% de estudios similares · 17.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Balance, Gait, and Falls Prevention · Bone health and osteoporosis research
- Palabras clave
- vitamin D supplementation, falls, fall prevention, calcium supplementation, trial sequential analysis, futility boundaries, type I error, randomized controlled trials, subgroup analysis
- MeSH
- humans, calcium, dietary, vitamin d, accidental falls, dietary supplements, aged, aged, 80 and over, female, male, randomized controlled trials as topic
4 autores
- Mark J Bolland🇳🇿University of Auckland
- Andrew B. Grey🇳🇿University of Auckland
- Greg D. Gamble🇳🇿University of Auckland
- Ian R. Reid🇳🇿University of Auckland
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Vitamin D supplementation is often recommended to prevent falls, although vitamin D trials and meta-analyses of these trials have reported conflicting results for this outcome. We aimed to assess if there was a need for further research.
Methods
We explored the value of doing further randomised controlled trials assessing the effects of vitamin D supplements on falls with trial sequential analysis with a risk reduction threshold of 15%. All analyses were done using the numbers of participants who had a fall in intention-to-treat analyses. Trial sequential analysis performs a cumulative meta-analysis, but reduces the risk of false-positive results from repetitive statistical testing by maintaining the overall risk of type 1 error at 5%.
Findings
In 20 existing randomised controlled trials (n=29,535), the effect estimate for vitamin D with or without calcium on falls lay within the futility boundary, providing evidence that vitamin D supplementation does not alter the relative risk by 15% or more. In a sensitivity analysis using a risk reduction threshold of 10%, the effect estimate also lay within the futility boundary. In subgroup analyses using a risk reduction threshold of 15%, the effect estimate also lay within the futility boundary for trials of vitamin D supplementation (16 trials, n=22,291) and trials of vitamin D with calcium (six trials, n=9919).
Interpretation
In pooled analyses, supplementation with vitamin D, with or without calcium, does not reduce falls by 15% or more. Future trials with similar designs are unlikely to alter these conclusions. At present, there is little justification for prescribing vitamin D supplements to prevent falls.
Funding
Health Research Council of New Zealand.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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