Effect of probiotic (VSL#3) and omega-3 on lipid profile, insulin sensitivity, inflammatory markers, and gut colonization in overweight adults: a randomized, controlled trial
Rajkumar H, Mahmood N, Kumar M, Varikuti SR, Challa HR, Myakala SP
Mediators of inflammation · 202 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Nutrition, Hyderabad, India
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-01-01 · Mediators Inflamm · vol. 2014 · págs. 1–8
- Editorial
- Hindawi Publishing Corporation
- Citado
- 301 citas · más que el 100% de estudios similares · 25.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Probiotics and Fermented Foods · Gut microbiota and health · Fatty Acid Research and Health
- Palabras clave
- omega-3 fatty acids, overweight adults, lipid profile, insulin sensitivity, insulin resistance, inflammatory markers, C-reactive protein, gut microbiota, HDL cholesterol, LDL cholesterol, triglycerides, lactobacilli, Bifidobacterium, Escherichia coli, Bacteroides
- MeSH
- gastrointestinal tract, humans, insulin resistance, inflammation, cholesterol, lipids, fatty acids, omega-3, triglycerides, probiotics, adult, middle aged, female, male, overweight, cholesterol, ldl, cholesterol, hdl
6 autores
- Hemalatha Rajkumar🇮🇳Indian Council of Medical Research; National Institute of Nutrition
- Naseha Mahmood🇮🇳Indian Council of Medical Research; National Institute of Nutrition
- Manoj Kumar🇮🇳 · autor de correspondenciaIndian Council of Medical Research; National Institute of Nutrition
- Sudarshan Reddy Varikuti🇮🇳Indian Council of Medical Research; National Institute of Nutrition
- Hanumanth Reddy Challa🇮🇳Indian Council of Medical Research; National Institute of Nutrition
- Shiva Prakash Myakala🇮🇳Indian Council of Medical Research; National Institute of Nutrition
Resumen
El texto original del estudio, en el idioma en que se publicó.
To evaluate the effects of probiotic (VSL#3) and omega-3 fatty acid on insulin sensitivity, blood lipids, and inflammation, we conducted a clinical trial in 60 overweight (BMI > 25), healthy adults, aged 40-60 years. After initial screening the subjects were randomized into four groups with 15 per group. The four groups received, respectively, placebo, omega-3 fatty acid, probiotic VSL#3, or both omega-3 and probiotic, for 6 weeks. Blood and fecal samples were collected at baseline and after 6 weeks. The probiotic (VSL#3) supplemented group had significant reduction in total cholesterol, triglyceride, LDL, and VLDL and had increased HDL (P < 0.05) value. VSL#3 improved insulin sensitivity (P < 0.01), decreased hsCRP, and favorably affected the composition of gut microbiota. Omega-3 had significant effect on insulin sensitivity and hsCRP but had no effect on gut microbiota. Addition of omega-3 fatty acid with VSL#3 had more pronounced effect on HDL, insulin sensitivity and hsCRP. Subjects with low HDL, insulin resistance, and high hsCRP had significantly lower total lactobacilli and bifidobacteria count and higher E. coli and bacteroides count.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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