Nut consumption and risk of type 2 diabetes, cardiovascular disease, and all-cause mortality: a systematic review and meta-analysis
Luo C, Zhang Y, Ding Y, Shan Z, Chen S, Yu M, Hu FB, Liu L
The American journal of clinical nutrition · 164 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- National Science and Technology Support Program
- Subvenciones
- National Natural Science Foundation of China (81072291); National Natural Science Foundation of China (NSFC 81072291)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-05-22 · Am J Clin Nutr · vol. 100 · número 1 · págs. 256–269
- Editorial
- Elsevier BV
- Citado
- 249 citas · más que el 93% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Nutrition, Genetics, and Disease
- Palabras clave
- nut consumption, type 2 diabetes, cardiovascular disease, all-cause mortality, ischemic heart disease, stroke, body mass index, dietary intake, disease risk, prospective cohort, dose-response relationship, Mediterranean diet, Mediterranean diet score, Mediterranean diet adherence
- MeSH
- humans, nuts, cardiovascular diseases, diabetes mellitus, type 2, diet, incidence, risk factors, sensitivity and specificity, databases, factual
8 autores
- Cheng Luo🇨🇳Huazhong University of Science and Technology
- Yan Zhang🇨🇳Huazhong University of Science and Technology
- Yusong Ding🇨🇳Huazhong University of Science and Technology
- Zhilei Shan🇨🇳Huazhong University of Science and Technology
- Sijing Chen🇨🇳Huazhong University of Science and Technology
- Miao Yu🇨🇳Huazhong University of Science and Technology
- Frank B. Hu🇨🇳Huazhong University of Science and Technology
- Liegang Liu🇨🇳Huazhong University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Epidemiologic studies have shown inverse associations between nut consumption and diabetes, cardiovascular disease (CVD), and all-cause mortality, but results have not been consistent.
Objective
We assessed the relation between nut intake and incidence of type 2 diabetes, CVD, and all-cause mortality.
Design
We searched PubMed and EMBASE for all prospective cohort studies published up to March 2013 with RRs and 95% CIs for outcomes of interest. A random-effects model was used to pool risk estimates across studies.
Results
In 31 reports from 18 prospective studies, there were 12,655 type 2 diabetes, 8862 CVD, 6623 ischemic heart disease (IHD), 6487 stroke, and 48,818 mortality cases. The RR for each incremental serving per day of nut intake was 0.80 (95% CI: 0.69, 0.94) for type 2 diabetes without adjustment for body mass index; with adjustment, the association was attenuated [RR: 1.03; 95% CI: 0.91, 1.16; NS]. In the multivariable-adjusted model, pooled RRs (95% CIs) for each serving per day of nut consumption were 0.72 (0.64, 0.81) for IHD, 0.71 (0.59, 0.85) for CVD, and 0.83 (0.76, 0.91) for all-cause mortality. Pooled RRs (95% CIs) for the comparison of extreme quantiles of nut intake were 1.00 (0.84, 1.19; NS) for type 2 diabetes, 0.66 (0.55, 0.78) for IHD, 0.70 (0.60, 0.81) for CVD, 0.91 (0.81, 1.02; NS) for stroke, and 0.85 (0.79, 0.91) for all-cause mortality.
Conclusions
Our meta-analysis indicates that nut intake is inversely associated with IHD, overall CVD, and all-cause mortality but not significantly associated with diabetes and stroke. The inverse association between the consumption of nuts and diabetes was attenuated after adjustment for body mass index. These findings support recommendations to include nuts as part of a healthy dietary pattern for the prevention of chronic diseases.
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