Near-infrared low-level laser stimulation of telocytes from human myometrium
Campeanu RA, Radu BM, Cretoiu SM, Banciu DD, Banciu A, Cretoiu D, Popescu LM
Lasers in medical science · 41 citas
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Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Autoritatea Natională pentru Cercetare Stiintifică
- Gobierno
- Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii
- Subvenciones
- Autoritatea Natională pentru Cercetare Stiintifică (82/2012); Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii (PN-II-PT-PCCA-2011-3)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-05-28 · Lasers Med Sci · vol. 29 · número 6 · págs. 1867–1874
- Editorial
- Springer Science+Business Media
- Citado
- 60 citas · más que el 95% de estudios similares · 4.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Genetics, Aging, and Longevity in Model Organisms · Laser Applications in Dentistry and Medicine · Planarian Biology and Electrostimulation
- Palabras clave
- Myometrium, Stimulation, Internal medicine, Endocrinology, Andrology, Chemistry, Medicine, Uterus
- MeSH
- myometrium, uterus, humans, neodymium, receptor, platelet-derived growth factor alpha, antigens, cd34, biopsy, hysterectomy, pregnancy, adult, middle aged, female, lasers, solid-state, low-level light therapy, telocytes
7 autores
- Razvan-Alexandru Campeanu🇷🇴University of Bucharest
- Beatrice Mihaela Radu🇮🇹🇷🇴University of Verona; University of Bucharest
- Sanda Maria Creţoiu🇷🇴Carol Davila University of Medicine and Pharmacy; Institutul National Victor Babes
- Daniel Dumitru Banciu🇷🇴University of Bucharest
- Adela Banciu🇷🇴University of Bucharest
- Dragoş Crețoiu🇷🇴Carol Davila University of Medicine and Pharmacy; Institutul National Victor Babes
- Laurentiu Mircea Popescu🇷🇴 · autor de correspondenciaCarol Davila University of Medicine and Pharmacy; Institutul National Victor Babes
Resumen
El texto original del estudio, en el idioma en que se publicó.
Telocytes (TCs) are a brand-new cell type frequently observed in the interstitial space of many organs (see www.telocytes.com ). TCs are defined by very long (tens of micrometers) and slender prolongations named telopodes. At their level, dilations-called podoms (~300 nm), alternate with podomers (80-100 nm). TCs were identified in a myometrial interstitial cell culture based on morphological criteria and by CD34 and PDGF receptor alpha (PDGFRα) immunopositivity. However, the mechanism(s) of telopodes formation and/or elongation and ramification is not known. We report here the low-level laser stimulation (LLLS) using a 1,064-nm neodymium-doped yttrium aluminum garnet (Nd:YAG) laser (with an output power of 60 mW) of the telopodal lateral extension (TLE) growth in cell culture. LLLS of TCs determines a higher growth rate of TLE in pregnant myometrium primary cultures (10.3 ± 1.0 μm/min) compared to nonpregnant ones (6.6 ± 0.9 μm/min). Acute exposure (30 min) of TCs from pregnant myometrium to 1 μM mibefradil, a selective inhibitor of T-type calcium channels, determines a significant reduction in the LLLS TLE growth rate (5.7 ± 0.8 μm/min) compared to LLLS per se in same type of samples. Meanwhile, chronic exposure (24 h) completely abolishes the LLLS TLE growth in both nonpregnant and pregnant myometria. The initial direction of TLE growth was modified by LLLS, the angle of deviation being more accentuated in TCs from human pregnant myometrium than in TCs from nonpregnant myometrium. In conclusion, TCs from pregnant myometrium are more susceptible of reacting to LLLS than those from nonpregnant myometrium. Therefore, some implications are emerging for low-level laser therapy (LLLT) in uterine regenerative medicine.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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