Replacing with whole grains and legumes reduces Lp-PLA2 activities in plasma and PBMCs in patients with prediabetes or T2D
Kim M, Jeung SR, Jeong TS, Lee SH, Lee JH
Journal of lipid research · 15 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-06-06 · J Lipid Res · vol. 55 · número 8 · págs. 1762–1771
- Editorial
- Elsevier BV
- Citado
- 21 citas · más que el 64% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Food composition and properties · Fatty Acid Research and Health · Lipoproteins and Cardiovascular Health
- Palabras clave
- Internal medicine, Endocrinology, Peripheral blood mononuclear cell, Insulin resistance, Lipoprotein, Chemistry, Glycated hemoglobin, Triglyceride, Glycemic, Insulin, Malondialdehyde, Type 2 diabetes, Medicine, Diabetes mellitus, Oxidative stress, Biochemistry, Cholesterol
- MeSH
- leukocytes, mononuclear, humans, fabaceae, diabetes mellitus, type 2, prediabetic state, malondialdehyde, 1-alkyl-2-acetylglycerophosphocholine esterase, lipoproteins, ldl, middle aged, female, male, whole grains
5 autores
- Minjoo Kim🇰🇷Yonsei University
- Se Ri Jeung🇰🇷Yonsei University
- Tae‐Sook Jeong🇰🇷Korea Research Institute of Bioscience and Biotechnology
- Sang‐Hyun Lee🇰🇷National Health Insurance Service
- Jong Ho Lee🇰🇷 · autor de correspondenciaYonsei University; National Health Insurance Service
Resumen
El texto original del estudio, en el idioma en que se publicó.
To determine dietary effects on circulating lipoprotein-associated phospholipase A2 (Lp-PLA2) activity and enzyme activity in peripheral blood mononuclear cells (PBMCs), 99 patients with impaired fasting glucose, impaired glucose tolerance, or newly-diagnosed T2D were randomly assigned to either a control group (usual diet with refined rice) or the whole grain and legume group. Substitution of whole grains and legumes for refined rice was associated with the replacement of 7% of energy from carbohydrates with energy from protein (about 4%) and fat. After 12 weeks, the whole grain and legume group showed a significant decrease in fasting glucose, insulin, homeostasis model assessment-insulin resistance, hemoglobin A1c, malondialdehyde, plasma Lp-PLA2 activity, and oxidized LDL (ox-LDL), and an increase in LDL particle size. The changes (Δs) in these variables in the whole grain and legume group were significantly different from those in controls after adjustment for the baseline levels. When all subjects were considered, Δ plasma Lp-PLA2 positively correlated with Δ glucose, Δ PBMC Lp-PLA2, Δ ox-LDL, and Δ urinary 8-epi-prostaglandin F2α after being adjusted for confounding factors. The Δ PBMC Lp-PLA2 correlated positively with Δ glucose and Δ ox-LDL, and negatively with Δ LDL particle size and baseline PBMC Lp-PLA2 The substitution of whole grains and legumes for refined rice resulted in a reduction in Lp-PLA2 activities in plasma and PBMCs partly through improved glycemic control, increased consumption of protein relative to carbohydrate, and reduced lipid peroxides.
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