Effect of broccoli sprouts on nasal response to live attenuated influenza virus in smokers: a randomized, double-blind study
Noah TL, Zhang H, Zhou H, Glista-Baker E, Müller L, Bauer RN, Meyer M, Murphy PC, Jones S, Letang B, Robinette C, Jaspers I
PloS one · 38 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (P30-ES010126); National Institute of Environmental Health Sciences (T32 ES007126); National Institute of Environmental Health Sciences (R01ES013611)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-06-09 · PLoS One · vol. 9 · número 6 · pág. e98671
- Editorial
- Public Library of Science
- Citado
- 44 citas · más que el 80% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Influenza Virus Research Studies · Respiratory viral infections research
- Palabras clave
- broccoli sprouts, sulforaphane, Nrf2, smokers, live attenuated influenza vaccine, nasal lavage fluid, interleukin-6, influenza virus replication, NAD(P)H:quinone oxidoreductase, nasal epithelium, dietary antioxidants, innate immunity
- MeSH
- nose, nasal lavage fluid, humans, orthomyxoviridae, brassica, plant shoots, nad(p)h dehydrogenase (quinone), plant extracts, vaccines, attenuated, influenza vaccines, double-blind method, smoking, gene expression regulation, adult, female, male, heme oxygenase-1, influenza a virus, h3n2 subtype, influenza a virus, h1n1 subtype
12 autores
- Terry L. Noah🇺🇸 · autor de correspondenciaUniversity of North Carolina at Chapel Hill
- Hongtao Zhang🇺🇸University of North Carolina at Chapel Hill
- Haibo Zhou🇺🇸University of North Carolina at Chapel Hill
- Ellen E. Glista-Baker🇺🇸University of North Carolina at Chapel Hill
- Loretta L. Müller🇨🇭University Children’s Hospital Basel
- Rebecca N. Bauer🇺🇸University of North Carolina at Chapel Hill
- Megan Meyer🇺🇸University of North Carolina at Chapel Hill
- Paula C. Murphy🇺🇸University of North Carolina at Chapel Hill
- Shannon Jones🇺🇸University of North Carolina at Chapel Hill
- Blanche Letang🇺🇸University of North Carolina at Chapel Hill
- Carole Robinette🇺🇸University of North Carolina at Chapel Hill
- Ilona Jaspers🇺🇸University of North Carolina at Chapel Hill
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Smokers have increased susceptibility and altered innate host defense responses to influenza virus infection. Broccoli sprouts are a source of the Nrf2 activating agentsulforaphane, and short term ingestion of broccoli sprout homogenates (BSH) has been shown to reduce nasal inflammatory responses to oxidant pollutants.
Objectives
Assess the effects of BSH on nasal cytokines, virus replication, and Nrf2-dependent enzyme expression in smokers and nonsmokers.
Methods
We conducted a randomized, double-blind, placebo-controlled trial comparing the effects of BSH on serially sampled nasal lavage fluid (NLF) cytokines, viral sequence quantity, and Nrf2-dependent enzyme expression in NLF cells and biopsied epithelium. Healthy young adult smokers and nonsmokers ingested BSH or placebo (alfalfa sprout homogenate) for 4 days, designated Days -1, 0, 1, 2. On Day 0 they received standard vaccine dose of live attenuated influenza virus (LAIV) intranasally. Nasal lavage fluids and nasal biopsies were collected serially to assess response to LAIV.
Results
In area under curve analyses, post-LAIV IL-6 responses (P = 0.03) and influenza sequences (P = 0.01) were significantly reduced in NLF from BSH-treated smokers, while
Nad(p)h
quinoneoxidoreductasein NLF cells was significantly increased. In nonsmokers, a similar trend for reduction in virus quantity with BSH did not reach statistical significance.
Conclusions
In smokers, short term ingestion of broccoli sprout homogenates appears to significantly reduce some virus-induced markers of inflammation, as well as reducing virus quantity. Nutritional antioxidant interventions have promise as a safe, low-cost strategy for reducing influenza risk among smokers and other at risk populations.
Trial registration
ClinicalTrials.gov NCT01269723.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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