Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China
Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Muñoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW
Cancer prevention research (Philadelphia, Pa.) · 150 citas
Etiquetas de revisión
Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (P30 ES 003819); National Institute of Environmental Health Sciences (P01 ES006052)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-06-10 · Cancer Prev Res (Phila) · vol. 7 · número 8 · págs. 813–823
- Editorial
- American Association for Cancer Research
- Citado
- 192 citas · más que el 98% de estudios similares · 7.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Air Quality and Health Impacts
- Palabras clave
- Sulforaphane, Mercapturic acid, Glucoraphanin, Excretion, Chemistry, Cruciferous vegetables, Urine, Glutathione, Food science, Glucosinolate, Bioavailability, Brassica, Pharmacology, Medicine, Biochemistry, Botany, Biology, Enzyme, Internal medicine
- MeSH
- humans, brassica, oximes, imidoesters, isothiocyanates, sulfoxides, glutathione transferase, glucosinolates, air pollutants, chromatography, liquid, air pollution, biological availability, genotype, polymorphism, single nucleotide, time factors, beverages, adult, aged, middle aged, china, female, male, mass spectrometry, young adult, biomarkers
18 autores
- Patricia A. Egner🇺🇸Johns Hopkins University
- Jianguo Chen🇨🇳Qidong Liver Cancer Prevention Research
- Adam T. Zarth🇺🇸University of Minnesota; University of Minnesota Medical Center
- Derek K. Ng🇺🇸Johns Hopkins University
- Jin-Bing Wang🇨🇳Qidong Liver Cancer Prevention Research
- Kevin H. Kensler🇺🇸Johns Hopkins University
- Lisa P. Jacobson🇺🇸Johns Hopkins University
- Álvaro Muñoz🇺🇸Johns Hopkins University
- Jamie L. Johnson🇺🇸Johns Hopkins University
- John D. Groopman🇺🇸Johns Hopkins University
- Jed W. Fahey🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Paul Talalay🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Jian Zhu🇨🇳Qidong Liver Cancer Prevention Research
- Tao-Yang Chen🇨🇳Qidong Liver Cancer Prevention Research
- Geng-Sun Qian🇨🇳Qidong Liver Cancer Prevention Research
- Steven G. Carmella🇺🇸University of Minnesota; University of Minnesota Medical Center
- Stephen S. Hecht🇺🇸University of Minnesota; University of Minnesota Medical Center
- Thomas W. Kensler🇺🇸Johns Hopkins University; University of Pittsburgh; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can generate the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases (GST) and other cytoprotective enzymes. A broccoli sprout-derived beverage providing daily doses of 600 μmol glucoraphanin and 40 μmol sulforaphane was evaluated for magnitude and duration of pharmacodynamic action in a 12-week randomized clinical trial. Two hundred and ninety-one study participants were recruited from the rural He-He Township, Qidong, in the Yangtze River delta region of China, an area characterized by exposures to substantial levels of airborne pollutants. Exposure to air pollution has been associated with lung cancer and cardiopulmonary diseases. Urinary excretion of the mercapturic acids of the pollutants, benzene, acrolein, and crotonaldehyde, were measured before and during the intervention using liquid chromatography tandem mass spectrometry. Rapid and sustained, statistically significant (P ≤ 0.01) increases in the levels of excretion of the glutathione-derived conjugates of benzene (61%), acrolein (23%), but not crotonaldehyde, were found in those receiving broccoli sprout beverage compared with placebo. Excretion of the benzene-derived mercapturic acid was higher in participants who were GSTT1-positive than in the null genotype, irrespective of study arm assignment. Measures of sulforaphane metabolites in urine indicated that bioavailability did not decline over the 12-week daily dosing period. Thus, intervention with broccoli sprouts enhances the detoxication of some airborne pollutants and may provide a frugal means to attenuate their associated long-term health risks.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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