The Effects of Tocotrienols Added to Canola Oil on Microalbuminuria, Inflammation, and Nitrosative Stress in Patients with Type 2 Diabetes: A Randomized, Double-blind, Placebo-controlled Trial
Haghighat N, Vafa M, Eghtesadi S, Heidari I, Hosseini A, Rostami A
International journal of preventive medicine · 27 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-05-01 · Int J Prev Med · vol. 5 · número 5 · págs. 617–23
- Editorial
- National Institutes of Health
- Citado
- 28 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 22 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-SA
- Áreas de investigación
- Coconut Research and Applications · Antioxidant Activity and Oxidative Stress · Fatty Acid Research and Health
- Palabras clave
- Microalbuminuria, Medicine, Placebo, Urine, Creatinine, Canola, Internal medicine, Proteinuria, Randomized controlled trial, Endocrinology, Gastroenterology, Renal function, Kidney, Food science, Chemistry, Pathology
6 autores
- Neda Haghighat🇮🇷Tehran University of Medical Sciences
- Mohammadreza Vafa🇮🇷Iran University of Medical Sciences; Tehran University of Medical Sciences
- Shahryar Eghtesadi🇮🇷Tehran University of Medical Sciences
- Iraj Heidari🇮🇷Iran University of Medical Sciences
- Agha Fatemeh Hosseini🇮🇷Iran University of Medical Sciences
- Ali Rostami🇮🇷Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Tocotrienols (T3) were neglected in the past; today, get attentions due to their antioxidant and none-antioxidant activity. The objective of this study was to evaluate the effects of the daily intake of 200 mg T3 added in canola oil over 8 weeks on microalbuminuria, inflammation, and nitrosative stress in type 2 diabetic patients.
Methods
This study was a double-blinded, placebo-controlled, randomized trial. A total of 50 patients with T2DM and FBS >126 mg/dl treated by non-insulin hypoglycemic drugs were randomly assigned to receive either 15 ml T3-enriched canola oil (200 mg/day T3) or pure canola oil for 8 weeks. Urine microalbumin, volume and creatinine levels, serum hs-CRP, and nitric oxide (NO) levels were measured before and after intervention.
Results
From 50 patients participated in this study, 44 completed the study. There were no significant differences in baseline characteristics, dietary intake, and physical activity between groups. Urine microalbumin and serum hs-CRP were declined significantly in T3-treated group. At the end of the study, patients who treated with T3 had lower urine microalbumin (11 (9, 25) vs. 22 (15, 39.75) nmol/dl, P = 0.003) and hs-CRP changes (-10.91 ± 15.5 vs. -9.88 ± 27.5 Pg/ml, P = 0.048) than control group. A non-significant decrease was also observed in serum NO level in T3-treated group with no changes in urine volume and creatinine levels.
Conclusions
These findings indicate that T3 leads to ameliorate proteinuria and can protect the kidney against inflammation (hs-CRP) and nitrosative stress (NO).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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