Financiado en parte por Ferring
Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review
Irani M, Merhi Z
Fertility and sterility · 204 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas, más trabajo en animales o laboratorio
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Ferring
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-06-03 · Fertil Steril · vol. 102 · número 2 · págs. 460–468.e3
- Editorial
- Elsevier BV
- Citado
- 317 citas · más que el 91% de estudios similares · 3.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 93 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Ovarian function and disorders · Reproductive Biology and Fertility · Vitamin D Research Studies
- Palabras clave
- vitamin D, ovarian physiology, polycystic ovary syndrome, ovarian reserve, anti-Müllerian hormone, granulosa cells, folliculogenesis, steroidogenesis, progesterone secretion, luteinization, soluble receptor for advanced glycation end products, anti-inflammatory activity, vitamin D supplementation, assisted reproduction, IVF outcomes, controlled ovarian stimulation, ovulatory dysfunction
- MeSH
- ovary, ovarian follicle, animals, humans, polycystic ovary syndrome, infertility, female, vitamin d deficiency, vitamin d, treatment outcome, reproductive techniques, assisted, signal transduction, fertility, pregnancy, dietary supplements, female, male
2 autores
- Mohamad Irani🇺🇸Maimonides Medical Center
- Zaher O Merhi🇺🇸 · autor de correspondenciaUniversity of Vermont; University of Vermont Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To report an update on the role of vitamin D (VD) in ovarian physiology with a focus on genes involved in steroidogenesis, follicular development, and ovarian reserve, as well as ovulatory dysfunction associated with polycystic ovary syndrome (PCOS), and ovarian response to assisted reproductive technology (ART).
Design
Systematic review.
Setting
Not applicable.
Patient(s)
Human, animal, and cell culture models.
Intervention(s)
Pubmed literature search.
Main outcome measure(s)
Granulosa cell function, serum antimüllerian hormone (AMH), AMH and its receptor gene expression, soluble receptor for advanced glycation end-products (sRAGE), PCOS parameters, and ART outcome.
Result(s)
In human granulosa cells, VD alters AMH signaling, FSH sensitivity, and progesterone production and release, indicating a possible physiologic role for VD in ovarian follicular development and luteinization. In the serum, 25-hydroxyvitamin D (25OH-D) is positively correlated with AMH, and appropriate VD supplementation in VD-depleted women can suppress the seasonal changes that occur in serum AMH. In VD-deficient women with PCOS, VD supplementation lowers the abnormally elevated serum AMH levels, possibly indicating a mechanism by which VD improves folliculogenesis. The antiinflammatory sRAGE serum levels significantly increase in women with PCOS after VD replacement. Although follicular fluid 25OH-D correlates with IVF outcomes, there is a lack of data pertaining to the impact of VD supplementation on pregnancy rates following IVF.
Conclusion(s)
This review underscores the need for understanding the mechanistic actions of VD in ovarian physiology and the critical need for randomized trials to elucidate the impact of VD supplementation on controlled ovarian hyperstimulation/IVF outcome and ovulatory dysfunction associated with PCOS.
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