Creatine for Parkinson's disease
Xiao Y, Luo M, Luo H, Wang J
The Cochrane database of systematic reviews · 10 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-06-17 · Cochrane Database Syst Rev · vol. 2014 · número 6 · pág. CD009646
- Editorial
- Elsevier BV
- Citado
- 18 citas · más que el 77% de estudios similares · 1.2× el promedio de su campo
- Referencias
- 30 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Parkinson's Disease Mechanisms and Treatments · Coenzyme Q10 studies and effects · Neurological Disorders and Treatments
- Palabras clave
- creatine, Parkinson's disease, mitochondrial dysfunction, adjuvant therapy, motor function, activities of daily living, quality of life, gastrointestinal adverse effects, neurodegeneration
- MeSH
- humans, parkinson disease, creatine, neuroprotective agents, activities of daily living, quality of life, randomized controlled trials as topic
4 autores
- Yousheng Xiao🇨🇳Guangxi Medical University; First Affiliated Hospital of GuangXi Medical University
- Man Luo🇨🇳Guangxi Medical University; First Affiliated Hospital of GuangXi Medical University
- Hongye Luo🇨🇳Guangxi Medical University
- Jin Wang🇨🇳Guangxi Medical University; First Affiliated Hospital of GuangXi Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Parkinson's disease is one of the most common neurodegenerative disorders and mitochondrial dysfunction plays an important role in its pathogenesis. Creatine is effective in improving mitochondrial function. It may therefore be useful for slowing the progression of Parkinson's disease.
Objectives
To assess the efficacy and safety of creatine used alone or as an adjuvant treatment for Parkinson's disease.
Search methods
We searched the Cochrane Movement Disorders Group Trials Register, CENTRAL (The Cochrane Library 2013, November Issue 4), MEDLINE (January 1966 to 10 November 2013), EMBASE (1974 to 10 November 2013) and two Chinese databases. We searched ongoing trials registers and conference proceedings, checked reference lists and contacted authors of included trials.
Selection criteria
Randomized controlled trials (RCTs) comparing creatine versus placebo for Parkinson's disease.
Data collection and analysis
Two review authors independently selected the trials for inclusion, assessed trial quality and extracted data.
Main results
We included two RCTs with a total of 194 patients. Both trials compared creatine with placebo for Parkinson's disease and both had methodological limitations. There was no clear evidence of an effect on motor function (MD -0.26; 95% confidence interval (CI) -4.39 to 3.88, low quality evidence), activities of daily living (MD 0.37; 95% CI -1.28 to 2.02, low quality evidence) or quality of life after one or two years of treatment. One trial reported serious adverse events that were not attributed to creatine. Also, one trial observed higher rates of gastrointestinal effects at two years follow-up.
Authors' conclusions
The evidence base on the effects of creatine in Parkinson's disease is limited by risk of bias, small sample sizes and short duration of the eligible trials. It does not provide a reliable basis on which treatment decisions can be made. Future well-designed RCTs with larger sample size and long-term follow-up are needed to assess creatine for Parkinson's disease.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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