Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States
Schöttker B, Jorde R, Peasey A, Thorand B, Jansen EH, Groot Ld, Streppel M, Gardiner J, Ordóñez-Mena JM, Perna L, Wilsgaard T, Rathmann W, Feskens E, Kampman E, Siganos G, Njølstad I, Mathiesen EB, Kubínová R, Pająk A, Topor-Madry R, Tamosiunas A, Hughes M, Kee F, Bobak M, Trichopoulou A, Boffetta P, Brenner H, Consortium on Health and Ageing: Network of Cohorts in Europe and the United States
BMJ (Clinical research ed.) · 290 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Universitetet i Tromsø
- Organización sin fines de lucro
- Wellcome Trust
- Gobierno
- European Commission
- Gobierno
- Deutsche Forschungsgemeinschaft
- Gobierno
- Bundesministerium für Bildung und Forschung
- Gobierno
- Bundesministerium für Gesundheit
- Gobierno
- Norges Forskningsråd
- Organización sin fines de lucro
- Deutsche Krebshilfe
- Universidad u hospital
- Universität Ulm
- Organización sin fines de lucro
- Hellenic Health Foundation
- Gobierno
- Medical Research Council
- Universidad u hospital
- Helmholtz Zentrum München
- Gobierno
- National Institute on Aging
- Gobierno
- NIA NIH HHS
- Subvenciones
- Wellcome Trust (064947); Medical Research Council (MR/K023241/1); Deutsche Krebshilfe (108426); Deutsche Forschungsgemeinschaft (TH-784/2–1); Deutsche Forschungsgemeinschaft (TH-784/2-1 and TH-784/2-2); Deutsche Krebshilfe (108250); Deutsche Forschungsgemeinschaft (TH-784/2–2); European Commission (242244); Wellcome Trust (081081); National Institute on Aging (R01AG23522-01)
Según 14 financiadores declarados.
Publicación
- Publicado
- 2014-06-17 · BMJ · vol. 348 · número jun17 16 · pág. g3656
- Citado
- 418 citas · más que el 99% de estudios similares · 8.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Skin Protection and Aging
- Palabras clave
- vitamin D, 25-hydroxyvitamin D, serum vitamin D levels, mortality, all-cause mortality, cardiovascular mortality, cancer mortality, seasonal variation, sex differences, country differences, dose-response relationship, middle-aged and older adults, vitamin D supplementation
- MeSH
- humans, neoplasms, cardiovascular diseases, vitamin d deficiency, vitamin d, cohort studies, seasons, age factors, sex factors, aged, middle aged, united states, europe, female, male
27 autores
- Ben Schöttker🇩🇪German Cancer Research Center
- Rolf Jorde🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Anne Peasey🇬🇧University College London
- Barbara Thorand🇩🇪Helmholtz Munich
- Eugène H.J.M. Jansen🇳🇱National Institute for Public Health and the Environment
- C.P.G.M. de Groot🇳🇱Wageningen University & Research
- Martinette T. Streppel🇳🇱Wageningen University & Research
- J. Gardiner🇬🇧University College London
- José Manuel Ordóñez-Mena🇩🇪German Cancer Research Center; Heidelberg University
- Laura Perna🇩🇪German Cancer Research Center
- Tom Wilsgaard🇳🇴UiT The Arctic University of Norway
- Wolfgang Rathmann🇩🇪Deutsches Diabetes-Zentrum e.V.; Heinrich Heine University Düsseldorf
- Edith J. M. Feskens🇳🇱Wageningen University & Research
- Ellen Kampman🇳🇱Wageningen University & Research
- Galatios Siganos🇳🇴UiT The Arctic University of Norway
- Inger Njølstad🇳🇴UiT The Arctic University of Norway
- Ellisiv Bøgeberg Mathiesen🇳🇴UiT The Arctic University of Norway
- Růžena Kubínová🇨🇿National Institute of Public Health
- A. Paj k🇵🇱Jagiellonian University
- Roman Topór‐Mądry🇵🇱Jagiellonian University
- Abdonas Tamošiūnas🇱🇹Lithuanian University of Health Sciences
- Maria Hughes🇬🇧Queen's University Belfast
- Frank Kee🇬🇧Queen's University Belfast
- Martin Bobák🇬🇧University College London
- Antonia Trichopoulou🇬🇷National and Kapodistrian University of Athens; Hellenic Health Foundation
- P. Boffetta🇬🇷🇺🇸Hellenic Health Foundation; Tisch Cancer Institute; Icahn School of Medicine at Mount Sinai
- Hermann Brenner🇩🇪German Cancer Research Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To investigate the association between serum 25-hydroxyvitamin D concentrations (25(OH)D) and mortality in a large consortium of cohort studies paying particular attention to potential age, sex, season, and country differences.
Design
Meta-analysis of individual participant data of eight prospective cohort studies from Europe and the US.
Setting
General population.
Participants
26,018 men and women aged 50-79 years.
Main outcome measures
All-cause, cardiovascular, and cancer mortality.
Results
25(OH)D concentrations varied strongly by season (higher in summer), country (higher in US and northern Europe) and sex (higher in men), but no consistent trend with age was observed. During follow-up, 6695 study participants died, among whom 2624 died of cardiovascular diseases and 2227 died of cancer. For each cohort and analysis, 25(OH)D quintiles were defined with cohort and subgroup specific cut-off values. Comparing bottom versus top quintiles resulted in a pooled risk ratio of 1.57 (95% CI 1.36 to 1.81) for all-cause mortality. Risk ratios for cardiovascular mortality were similar in magnitude to that for all-cause mortality in subjects both with and without a history of cardiovascular disease at baseline. With respect to cancer mortality, an association was only observed among subjects with a history of cancer (risk ratio, 1.70 (1.00 to 2.88)). Analyses using all quintiles suggest curvilinear, inverse, dose-response curves for the aforementioned relationships. No strong age, sex, season, or country specific differences were detected. Heterogeneity was low in most meta-analyses.
Conclusions
Despite levels of 25(OH)D strongly varying with country, sex, and season, the association between 25(OH)D level and all-cause and cause-specific mortality was remarkably consistent. Results from a long term randomised controlled trial addressing longevity are being awaited before vitamin D supplementation can be recommended in most individuals with low 25(OH)D levels.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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