Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial
Sharifi N, Amani R, Hajiani E, Cheraghian B
Endocrine · 190 citas
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Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-06-26 · Endocrine · vol. 47 · número 1 · págs. 70–80
- Editorial
- Springer Science+Business Media
- Citado
- 246 citas · más que el 100% de estudios similares · 15.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Liver Disease Diagnosis and Treatment · Antioxidant Activity and Oxidative Stress
- Palabras clave
- vitamin D supplementation, vitamin D3, non-alcoholic fatty liver disease, transaminases, oxidative stress, lipid peroxidation, malondialdehyde, C-reactive protein, TNF-α, insulin resistance, hepatic steatosis, 25-hydroxyvitamin D, systemic inflammation, antioxidant capacity
- MeSH
- liver, humans, insulin resistance, inflammation, vitamin d, c-reactive protein, oxidative stress, adult, middle aged, female, male, non-alcoholic fatty liver disease, biomarkers
4 autores
- Nasrin Sharifi🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Reza Amani🇮🇷 · autor de correspondenciaAhvaz Jundishapur University of Medical Sciences; Diabetes Research Center
- Eskandar Hajiani🇮🇷Ahvaz Jundishapur University of Medical Sciences
- Bahman Cheraghian🇮🇷Ahvaz Jundishapur University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
The aim of this study was to investigate the effects of vitamin D supplementation on serum aminotransferases, insulin resistance, oxidative stress, and inflammatory biomarkers in adult patients with non-alcoholic fatty liver disease (NAFLD). Fifty-three patients with NAFLD were enrolled in a parallel, double-blind, placebo-controlled study. The patients were randomly allocated to receive either one oral pearl consisting of 50,000 IU vitamin D3 (n = 27) or a placebo (n = 26), every 14 days for 4 months. Serum aminotransferases, high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor α, malondialdehyde (MDA), total antioxidant capacity, transforming growth factor β1, as well as grade of hepatic steatosis and homeostasis model assessment of insulin resistance were assessed pre- and post-intervention. In patients who received vitamin D supplement compared to the controls, the median of serum 25(OH)D3 significantly increased (16.2 vs. 1.6 ng/ml, P < 0.001). This increase accompanied by significant decrease in serum MDA (-2.09 vs. -1.23 ng/ml, P = 0.03) and near significant changes in serum hs-CRP (-0.25 vs. 0.22 mg/l, P = 0.06). These between-group differences remained significant even after controlling for baseline covariates. Other variables showed no significant changes. Improved vitamin D status led to amelioration in serum hs-CRP and MDA in patients with NAFLD. This might be considered as an adjunctive therapy to attenuate systemic inflammation and lipid peroxidation alongside other treatments for NAFLD patients.
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