Efficacy of some non-conventional herbal medications (sulforaphane, tanshinone IIA, and tetramethylpyrazine) in inducing neuroprotection in comparison with interleukin-10 after spinal cord injury: A meta-analysis
Koushki D, Latifi S, Norouzi Javidan A, Matin M
The journal of spinal cord medicine · 20 citas
Etiquetas de revisión
Financiación no declaradaSolo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Animales
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-06-26 · J Spinal Cord Med · vol. 38 · número 1 · págs. 13–22
- Editorial
- Taylor & Francis
- Citado
- 27 citas · más que el 36% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Spinal Cord Injury Research · Nerve injury and regeneration · Traumatic Brain Injury and Neurovascular Disturbances
- Palabras clave
- spinal cord injury, neuroprotection, sulforaphane, tanshinone IIA, tetramethylpyrazine, IL-10, herbal medicine, neuroinflammation, anti-inflammatory therapy, neurological recovery
- MeSH
- humans, spinal cord injuries, isothiocyanates, sulfoxides, pyrazines, neuroprotective agents, interleukin-10, herbal medicine, abietanes
4 autores
- Davood Koushki🇮🇷Iran University of Medical Sciences
- Sahar Latifi🇮🇷 · autor de correspondenciaTehran University of Medical Sciences
- Abbas Norouzi‐Javidan🇮🇷Tehran University of Medical Sciences
- Marzieh Matin🇮🇷Tehran University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Inflammation after spinal cord injury (SCI) may be responsible for further neural damages and therefore inhibition of inflammatory processes may exert a neuroprotection effect.
Objectives
To assess the efficacy of some non-conventional herbal medications including sulforaphane, tanshinone IIA, and tetramethylpyrazine in reducing inflammation and compare them with a known effective anti-inflammatory agent (interleukin-10 (IL-10)).
Methods
We searched relevant articles in Ovid database, Medline (PubMed) EMBASE, Google Scholar, Cochrane, and Scopus up to June 2013. The efficacy of each treatment and study powers were compared using random effects model of meta-analysis. To our knowledge, no conflict of interest exists.
Results
Eighteen articles entered into the study. The meta-analysis revealed that exogenous IL-10 was more effective in comparison with the mentioned herbal extracts. The proposed pathways for each medication's effect on reducing the inflammation process are complex and many overlaps may exist.
Conclusion
IL-10 has a strong effect in the induction of neuroprotection and neurorecovery after SCI by multiple pathways. Tetramethylpyrazine has an acceptable influence in reducing inflammation through the up-regulation of IL-10. Outcomes of sulforaphane and tanshinone IIA administration are acceptable but still weaker than IL-10.
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