Cardiac repolarization and autonomic regulation during short-term cold exposure in hypertensive men: an experimental study
Hintsala H, Kenttä TV, Tulppo M, Kiviniemi A, Huikuri HV, Mäntysaari M, Keinänen-Kiukaannemi S, Bloigu R, Herzig KH, Antikainen R, Rintamäki H, Jaakkola JJ, Ikäheimo TM
PloS one · 38 citas
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Terveyden ja hyvinvoinnin laitos
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-07-01 · PLoS One · vol. 9 · número 7 · pág. e99973
- Editorial
- Public Library of Science
- Citado
- 45 citas · más que el 85% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 50 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Heart Rate Variability and Autonomic Control · Blood Pressure and Hypertension Studies · Cardiac electrophysiology and arrhythmias
- Palabras clave
- Medicine, Internal medicine, QT interval, Cardiology, Heart rate, Population, Heart rate variability, Repolarization, Cardiac function curve, Endocrinology, Blood pressure, Heart failure, Electrophysiology
- MeSH
- heart conduction system, humans, hypertension, vectorcardiography, electrophysiologic techniques, cardiac, aged, middle aged, male, cold temperature
13 autores
- Heidi E. Hintsala🇫🇮Oulu University Hospital; University of Oulu
- Tuomas V Kenttä🇫🇮Oulu University Hospital; University of Oulu
- Mikko Paavo Tulppo🇬🇧London South Bank University
- Antti M. Kiviniemi
- Heikki V. Huikuri🇫🇮Oulu University Hospital; University of Oulu
- Matti Mäntysaari🇫🇮University of Oulu
- Sirkka Keinänen-Kiukaannemi🇫🇮Oulu University Hospital; University of Oulu
- Risto Bloigu🇫🇮University of Oulu
- Karl‐Heinz Herzig🇫🇮University of Eastern Finland; Oulu University Hospital; Kuopio University Hospital; University of Oulu
- Riitta Antikaínen🇫🇮Oulu University Hospital; University of Oulu
- Hannu Rintamäki🇫🇮Finnish Institute of Occupational Health; University of Oulu
- Jouni J. K. Jaakkola🇫🇮Oulu University Hospital; University of Oulu
- Tiina Maria Ikäheimo🇫🇮 · autor de correspondenciaOulu University Hospital; University of Oulu
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
The aim of our study was to assess the effect of short-term cold exposure, typical in subarctic climate, on cardiac electrical function among untreated middle-aged hypertensive men.
Methods
We conducted a population-based recruitment of 51 hypertensive men and a control group of 32 men without hypertension (age 55-65 years) who underwent whole-body cold exposure (15 min exposure to temperature -10°C, wind 3 m/s, winter clothes). Conduction times and amplitudes, vectorcardiography, arrhythmias, and heart rate variability (autonomic nervous function) were assessed.
Results
Short-term cold exposure increased T-peak to T-end interval from 67 to 72 ms (p<0.001) and 71 to 75 ms (p<0.001) and T-wave amplitude from 0.12 to 0.14 mV (p<0.001) and from 0.17 to 0.21 mV (p<0.001), while QTc interval was shortened from 408 to 398 ms (p<0.001) and from 410 to 401 ms (p<0.001) among hypertensive men and controls, respectively. Cold exposure increased both low (from 390 to 630 ms2 (p<0.001) and 380 to 700 ms2 (p<0.001), respectively) and high frequency heart rate variability (from 90 to 190 ms2 (p<0.001) and 150 to 300 ms2 (p<0.001), respectively), while low-to-high frequency-ratio was reduced. In addition, the frequency of ventricular ectopic beats increased slightly during cold exposure. The cold induced changes were similar between untreated hypertensive men and controls.
Conclusions
Short-term cold exposure with moderate facial and mild whole body cooling resulted in prolongation of T-peak to T-end interval and higher T-wave amplitude while QTc interval was shortened. These changes of ventricular repolarization may have resulted from altered cardiac autonomic regulation and were unaffected by untreated hypertension.
Trial registration
ClinicalTrials.gov NCT02007031.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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