A moderate-fat diet containing pistachios improves emerging markers of cardiometabolic syndrome in healthy adults with elevated LDL levels
Holligan SD, West SG, Gebauer SK, Kay CD, Kris-Etherton PM
The British journal of nutrition · 35 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Pennsylvania State University
- Gobierno
- National Institutes of Health
- Gobierno
- Natural Sciences and Engineering Research Council of Canada
- Gobierno
- National Center for Research Resources
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (M01 RR10732); National Institutes of Health (M01-RR-10-732)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2014-07-10 · Br J Nutr · vol. 112 · número 5 · págs. 744–752
- Editorial
- Cambridge University Press
- Citado
- 45 citas · más que el 90% de estudios similares · 2.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Natural Products and Biological Research · Phytochemicals and Antioxidant Activities
- Palabras clave
- Metabolic syndrome, Food science, Medicine, Triglycerides blood, Internal medicine, Obesity, Biology, Cholesterol, Triglyceride
- MeSH
- humans, pistacia, nuts, cardiovascular diseases, insulin resistance, cholesterol, sitosterols, phytosterols, dietary fats, triglycerides, lipoproteins, lipoproteins, ldl, c-reactive protein, anticholesteremic agents, phytotherapy, cross-over studies, middle aged, female, male, biomarkers, metabolic syndrome
5 autores
- Simone D. Holligan🇺🇸Pennsylvania State University
- Sheila G. West🇺🇸Pennsylvania State University
- Sarah K Gebauer🇺🇸Pennsylvania State University; Beltsville Agricultural Research Center
- Colin D. Kay🇬🇧🇺🇸University of East Anglia; Pennsylvania State University; Norwich Research Park
- Penny M. Kris‐Etherton🇺🇸 · autor de correspondenciaPennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
A randomised, cross-over, controlled-feeding study was conducted to evaluate the cholesterol-lowering effects of diets containing pistachios as a strategy for increasing total fat (TF) levels v. a control (step I) lower-fat diet. Ex vivo techniques were used to evaluate the effects of pistachio consumption on lipoprotein subclasses and functionality in individuals (n 28) with elevated LDL levels ( ≥ 2·86 mmol/l). The following test diets (SFA approximately 8 % and cholesterol < 300 mg/d) were used: a control diet (25 % TF); a diet comprising one serving of pistachios per d (1PD; 30 % TF); a diet comprising two servings of pistachios per d (2PD; 34 % TF). A significant decrease in small and dense LDL (sdLDL) levels was observed following the 2PD dietary treatment v. the 1PD dietary treatment (P= 0·03) and following the 2PD dietary treatment v. the control treatment (P= 0·001). Furthermore, reductions in sdLDL levels were correlated with reductions in TAG levels (r 0·424, P= 0·025) following the 2PD dietary treatment v. the control treatment. In addition, inclusion of pistachios increased the levels of functional α-1 (P= 0·073) and α-2 (P= 0·056) HDL particles. However, ATP-binding cassette transporter A1-mediated serum cholesterol efflux capacity (P= 0·016) and global serum cholesterol efflux capacity (P= 0·076) were only improved following the 2PD dietary treatment v. the 1PD dietary treatment when baseline C-reactive protein status was low ( < 103μg/l). Moreover, a significant decrease in the TAG:HDL ratio was observed following the 2PD dietary treatment v. the control treatment (P= 0·036). There was a significant increase in β-sitosterol levels (P< 0·0001) with the inclusion of pistachios, confirming adherence to the study protocol. In conclusion, the inclusion of pistachios in a moderate-fat diet favourably affects the cardiometabolic profile in individuals with an increased risk of CVD.
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