Effects of cold exposure on autonomic changes during the last rapid eye movement sleep transition and morning blood pressure surge in humans
Kuo TB, Hong CH, Hsieh IT, Lee GS, Yang CC
Sleep medicine · 14 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- National Yang-Ming University
Según 1 financiador declarado.
Publicación
- Publicado
- 2014-05-10 · Sleep Med · vol. 15 · número 8 · págs. 986–997
- Editorial
- Elsevier BV
- Citado
- 20 citas · más que el 84% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Heart Rate Variability and Autonomic Control · Circadian rhythm and melatonin · Sleep and Wakefulness Research
- Palabras clave
- cold exposure, ambient temperature, morning blood pressure surge, REM sleep onset, sleep-wake transition, sympathetic nervous system, autonomic nervous system activity, heart rate variability, REM sleep duration, cardiovascular events
- MeSH
- autonomic nervous system, humans, polysomnography, sleep, rem, circadian rhythm, blood pressure, male, cold temperature, young adult
5 autores
- Terry B.J. Kuo🇹🇼Taipei City Hospital; National Yang Ming University
- Cian-Hui Hong🇹🇼National Yang Ming University
- I-Te Hsieh🇹🇼National Yang Ming University
- Guo‐She Lee🇹🇼Taipei Municipal YangMing Hospital; Taipei City Hospital; National Yang Ming University
- Cheryl C.H. Yang🇹🇼Taipei Municipal YangMing Hospital; Taipei City Hospital; National Yang Ming University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Various studies have linked the occurrence of cardiovascular events and low ambient temperatures as well as the morning blood pressure surge (MBPS). We hypothesized that low ambient temperatures produce a higher sympathetic change during the last rapid eye movement (REM) sleep transition and that this may play an important role in cold-related cardiovascular events.
Methods
All experiments were carried out on 12 healthy male adults, aged 24.00±0.74 years, who participated in two experimental conditions randomly (>1 day apart): warm (23 °C) and cold (16°C). Blood pressure (BP) was measured every 30 min for 24 h by autonomic ambulatory BP monitoring. The electroencephalograms, electrocardiograms, ambient temperature, near-body temperature, and physical activity were recorded by miniature polysomnography for 24 h.
Results
The cold conditions resulted in: (i) higher MBPS than under warm conditions; (ii) significant and greater sympathetic index changes during the sleep-wake transition than during cover-to-uncover and supine-to-sit position tests; (iii) the non-REM-REM transition-related sympathetic elevation during the cold conditions being significantly higher in late sleep period than in early sleep period; (iv) at 1h prior to morning awakening, the value of total power of heart rate variability changes being significantly negatively correlated with the changes of near-body temperature; and (v) significantly higher arousal index and shorter average interval of REM periods than in warm conditions.
Conclusion
Cold exposure elevates the amplitude of MBPS and is associated with late sleep stage transition sympathetic activation, which might have important implications for cold-related cardiovascular events.
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