The effects of vitamin D on skeletal muscle strength, muscle mass, and muscle power: a systematic review and meta-analysis of randomized controlled trials
Beaudart C, Buckinx F, Rabenda V, Gillain S, Cavalier E, Slomian J, Petermans J, Reginster JY, Bruyère O
The Journal of clinical endocrinology and metabolism · 468 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-07-17 · J Clin Endocrinol Metab · vol. 99 · número 11 · págs. 4336–4345
- Editorial
- Oxford University Press
- Citado
- 674 citas · más que el 99% de estudios similares · 6.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 64 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health in Aging · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, skeletal muscle strength, muscle mass, muscle power, 25-hydroxyvitamin D, calcium supplementation, older adults, muscle function
- MeSH
- muscle, skeletal, humans, vitamin d, dietary supplements, middle aged, muscle strength, randomized controlled trials as topic
9 autores
- Charlotte Beaudart🇧🇪 · autor de correspondenciaUniversity of Liège
- Fanny Buckinx🇧🇪University of Liège
- Véronique Rabenda🇧🇪University of Liège
- Sophie Gillain🇧🇪Centre Hospitalier Universitaire de Liège
- Etienne Cavalier🇧🇪University of Liège
- Justine Slomian🇧🇪University of Liège
- Jean Pétermans🇧🇪Centre Hospitalier Universitaire de Liège
- Jean‐Yves Reginster🇧🇪University of Liège; Centre Hospitalier Universitaire de Liège
- Olivier Bruyère🇧🇪University of Liège
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
There is growing evidence that vitamin D plays a role on several tissues including skeletal muscle.
Objective
The aim was to summarize with a meta-analysis, the effects of vitamin D supplementation on muscle function.
Data sources
A systematic research of randomized controlled trials, performed between 1966 and January 2014 has been conducted on Medline, Cochrane Database of Systematics Reviews, Cochrane Central Register of Controlled and completed by a manual review of the literature and congressional abstracts.
Study selection
All forms and doses of vitamin D supplementation, with or without calcium supplementation, compared with placebo or control were included. Out of the 225 potentially relevant articles, 30 randomized controlled trials involving 5615 individuals (mean age: 61.1 years) met the inclusion criteria.
Data extraction
Data were extracted by two independent reviewers.
Data synthesis
Results revealed a small but significant positive effect of vitamin D supplementation on global muscle strength with a standardized mean difference (SMD) of 0.17 (P = .02). No significant effect was found on muscle mass (SMD 0.058; P = .52) or muscle power (SMD 0.057; P = .657). Results on muscle strength were significantly more important with people who presented a 25-hydroxyvitamin D level <30 nmol/L. Supplementation seems also more effective on people aged 65 years or older compared to younger subjects (SMD 0.25; 95% CI 0.01 to 0.48 vs SMD 0.03; 95% CI -0.08 to 0.14).
Conclusions
Vitamin D supplementation has a small positive impact on muscle strength, but additional studies are needed to define optimal treatment modalities, including dose, mode of administration, and duration.
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