Effect of low-level laser therapy on inflammatory mediator release during chemotherapy-induced oral mucositis: a randomized preliminary study
Silva GB, Sacono NT, Othon-Leite AF, Mendonça EF, Arantes AM, Bariani C, Duarte LG, Abreu MH, Queiroz-Júnior CM, Silva TA, Batista AC
Lasers in medical science · 48 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-07-18 · Lasers Med Sci · vol. 30 · número 1 · págs. 117–126
- Editorial
- Springer Science+Business Media
- Citado
- 76 citas · más que el 93% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Oral Health Pathology and Treatment
- Palabras clave
- low-level laser therapy, oral mucositis, hematopoietic stem cell transplantation, chemotherapy toxicity, inflammatory mediators, MMP-2, IL-10, cytokines, saliva, conditioning regimen, oral ulcers
- MeSH
- saliva, humans, leukemia, lymphoma, stomatitis, transforming growth factor beta, tumor necrosis factor-alpha, inflammation mediators, myeloablative agonists, interleukin-6, interleukin-10, transplantation conditioning, hematopoietic stem cell transplantation, adult, middle aged, female, male, matrix metalloproteinase 2, lasers, semiconductor, young adult, low-level light therapy
11 autores
- Geisa Badauy Lauria Silva🇧🇷Hospital Araújo Jorge
- Nancy Tomoko Sacono🇧🇷Universidade Federal de Goiás
- Angélica Ferreira Oton‐Leite🇧🇷Universidade Federal de Goiás
- Elismauro Francisco Mendonça🇧🇷Universidade Federal de Goiás
- Adriano de Moraes Arantes🇧🇷Hospital Araújo Jorge
- César Bariani🇧🇷Hospital Araújo Jorge
- Luciana Lobo Duartec🇧🇷Hospital Araújo Jorge
- Mauro Henrique Nogueira Guimarães de Abreu🇧🇷Universidade Federal de Minas Gerais
- Celso Martins Queiroz‐Junior🇧🇷Universidade Federal de Minas Gerais
- Tarcı́lia Aparecida Silva🇧🇷Universidade Federal de Minas Gerais
- Aline Carvalho Batista🇧🇷 · autor de correspondenciaUniversidade Federal de Goiás
Resumen
El texto original del estudio, en el idioma en que se publicó.
Patients undergoing hematopoietic stem cell transplantation (HSCT) are submitted to a conditioning regimen of high-dose chemotherapy, with or without radiation therapy, which usually results in oral ulcerations and mucosal barrier breakdown. Oral mucositis (OM) is a common and debilitating toxicity side effect of autologous and allogeneic HSCT. The aim of this study was to evaluate the effect of low-level laser therapy (LLLT) on the severity of OM and inflammatory mediator (TNF-α, IL-6, IL-1β, IL-10, TGF-β, metalloproteinases, and growth factors) levels in saliva and blood of HSCT patients. Thirty patients were randomly assigned to two groups: control (n = 15) and laser (n = 15). LLLT was applied from the first day of the conditioning regimen until day 7 post-HSCT (D + 7). Saliva and blood were collected from patients on admission (AD), D-1, D + 3, D + 7, and on marrow engraftment day (ME). Clinical results showed less severe OM in the laser group (p < 0.05). The LLLT group showed increased matrix metalloproteinase 2 (MMP-2) levels in saliva on D + 7 (p = 0.04). Significant differences were also observed for IL-10 on D + 7 and on ME in blood plasma, when compared to the control group (p < 0.05). No significant differences were seen in saliva or blood for the other inflammatory mediators investigated. LLLT was clinically effective in reducing the severity of chemotherapy-induced OM in HSCT patients, and its mechanism of action does not seem to be completely linked to the modulation of pro- or anti-inflammatory cytokines, growth factors or matrix metalloproteinases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.