Effects of 12 weeks high dose vitamin D3 treatment on insulin sensitivity, beta cell function, and metabolic markers in patients with type 2 diabetes and vitamin D insufficiency - a double-blind, randomized, placebo-controlled trial
Kampmann U, Mosekilde L, Juhl C, Moller N, Christensen B, Rejnmark L, Wamberg L, Orskov L
Metabolism: clinical and experimental · 105 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-06-18 · Metabolism · vol. 63 · número 9 · págs. 1115–1124
- Editorial
- Elsevier BV
- Citado
- 143 citas · más que el 99% de estudios similares · 12.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Diabetes Treatment and Management · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- vitamin D3 supplementation, colecalciferol, vitamin D insufficiency, type 2 diabetes, insulin sensitivity, insulin secretion, beta-cell function, insulin pulsatility, inflammation, blood pressure, lipid profile, HbA1c, 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D
- MeSH
- humans, diabetes mellitus, type 2, insulin resistance, vitamin d deficiency, cholecalciferol, calcifediol, calcitriol, insulin, c-peptide, inflammation mediators, severity of illness index, double-blind method, seasons, kinetics, dietary supplements, aged, middle aged, denmark, female, male, insulin-secreting cells, biomarkers, insulin secretion
8 autores
- Ulla Kampmann🇩🇰Aarhus University Hospital
- Leif Mosekilde🇩🇰Aarhus University Hospital
- Claus Bogh Juhl🇩🇰Hospital South West Jutland
- Niels Møller🇩🇰Aarhus University Hospital
- Britt Christensen🇩🇰Aarhus University Hospital
- Lars Rejnmark🇩🇰Aarhus University Hospital
- Louise Wamberg🇩🇰Hospital South West Jutland
- L. Ørskov🇩🇰Regionshospitalet Silkeborg
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Vitamin D insufficiency is common in subjects with type 2 diabetes. Observational studies suggest that vitamin D plays a role in the pathogenesis of type 2 diabetes. However, results of intervention studies have been inconsistent. We investigated the effects of improving vitamin D status on insulin sensitivity, insulin secretion, and inflammatory markers in patients with type 2 diabetes.
Materials/methods
A double blind, randomized, placebo controlled trial was conducted. Sixteen patients with type 2 diabetes and hypovitaminosis D were recruited. Eight patients received colecalciferol and (280 μg daily for 2 weeks, 140 μg daily for 10 weeks) and 8 patients received identical placebo tablets for 12 weeks. Before and after intervention, patients underwent IVGTT, hyperinsulinemic euglycemic clamp, assessment of baseline high-frequency insulin pulsatility, glucose-entrained insulin pulsatility, DXA scans, 24-hour-ambulatory blood pressure monitorings, and fasting blood samples.
Results
Serum-25(OH) vitamin D and serum-1,25(OH)₂ vitamin D increased significantly after 12 weeks in the intervention group (p=0.01, p=0.004). Serum-25(OH) vitamin D was also significantly higher in the vitamin D group compared to the placebo group (p=0.02) after intervention. Although no significant changes in insulin sensitivity, inflammation, blood pressure, lipid profile, or HbA1c were found, we observed borderline (p between 0.05 and 0.10) improvements of insulin secretion, in terms of c-peptide levels, first phase incremental AUC insulin and insulin secretory burst mass.
Conclusions
Improvement in vitamin D status does not improve insulin resistance, blood pressure, inflammation or HbA1c, but might increase insulin secretion in patients with established type 2 diabetes.
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