Dietary medium chain fatty acid supplementation leads to reduced VLDL lipolysis and uptake rates in comparison to linoleic acid supplementation
van Schalkwijk DB, Pasman WJ, Hendriks HF, Verheij ER, Rubingh CM, van Bochove K, Vaes WH, Adiels M, Freidig AP, de Graaf AA
PloS one · 28 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-07-21 · PLoS One · vol. 9 · número 7 · pág. e100376
- Editorial
- Public Library of Science
- Citado
- 34 citas · más que el 91% de estudios similares · 3.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 36 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Lipid metabolism and disorders · Lipid metabolism and biosynthesis
- Palabras clave
- medium-chain fatty acids, linoleic acid, dietary supplementation, lipoprotein subclasses, LDL subclasses, lipoprotein kinetics, body fat distribution, waist-to-hip ratio, PPAR activation, fatty acid elongation
- MeSH
- humans, dietary fats, fatty acids, linoleic acid, lipoproteins, ldl, lipoproteins, vldl, fasting, double-blind method, lipolysis, dietary supplements, adult, middle aged, male
10 autores
- Daniël B. van Schalkwijk🇳🇱Netherlands Organisation for Applied Scientific Research; Netherlands Bioinformatics Centre
- Wilrike J. Pasman🇳🇱Netherlands Organisation for Applied Scientific Research
- H. Hendriks🇳🇱Netherlands Organisation for Applied Scientific Research
- Elwin R. Verheij🇳🇱Netherlands Organisation for Applied Scientific Research
- Carina M. Rubingh🇳🇱Netherlands Organisation for Applied Scientific Research
- Kees van Bochove🇳🇱Netherlands Organisation for Applied Scientific Research
- Wouter H. J. Vaes🇳🇱Netherlands Organisation for Applied Scientific Research
- Martin Adiels🇸🇪University of Gothenburg
- Andreas P. Freidig🇳🇱Netherlands Organisation for Applied Scientific Research
- Albert A. de Graaf🇳🇱 · autor de correspondenciaNetherlands Organisation for Applied Scientific Research
Resumen
El texto original del estudio, en el idioma en que se publicó.
Dietary medium chain fatty acids (MCFA) and linoleic acid follow different metabolic routes, and linoleic acid activates PPAR receptors. Both these mechanisms may modify lipoprotein and fatty acid metabolism after dietary intervention. Our objective was to investigate how dietary MCFA and linoleic acid supplementation and body fat distribution affect the fasting lipoprotein subclass profile, lipoprotein kinetics, and postprandial fatty acid kinetics. In a randomized double blind cross-over trial, 12 male subjects (age 51±7 years; BMI 28.5±0.8 kg/m2), were divided into 2 groups according to waist-hip ratio. They were supplemented with 60 grams/day MCFA (mainly C8:0, C10:0) or linoleic acid for three weeks, with a wash-out period of six weeks in between. Lipoprotein subclasses were measured using HPLC. Lipoprotein and fatty acid metabolism were studied using a combination of several stable isotope tracers. Lipoprotein and tracer data were analyzed using computational modeling. Lipoprotein subclass concentrations in the VLDL and LDL range were significantly higher after MCFA than after linoleic acid intervention. In addition, LDL subclass concentrations were higher in lower body obese individuals. Differences in VLDL metabolism were found to occur in lipoprotein lipolysis and uptake, not production; MCFAs were elongated intensively, in contrast to linoleic acid. Dietary MCFA supplementation led to a less favorable lipoprotein profile than linoleic acid supplementation. These differences were not due to elevated VLDL production, but rather to lower lipolysis and uptake rates.
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