Financiado en parte por Shire
Cardiovascular disease and vitamin D supplementation: trial analysis, systematic review, and meta-analysis
Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M, RECORD Trial Group
The American journal of clinical nutrition · 194 citas
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Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiado por la industria
- Universidad u hospital
- Glasgow Caledonian University
- Gobierno
- Scottish Government
- Gobierno
- National Institute for Health and Care Research
- Universidad u hospital
- University of Southampton
- Universidad u hospital
- Newcastle University
- Universidad u hospital
- University of Aberdeen
- Empresa
- Shire
- Gobierno
- Chief Scientist Office, Scottish Government Health and Social Care Directorate
- Gobierno
- Medical Research Council
- Gobierno
- Chief Scientist Office
- Gobierno
- National Institute for Health Research (NIHR)
- Subvenciones
- National Institute for Health and Care Research (ACF-2012-15-002)
Según 11 financiadores declarados.
Publicación
- Publicado
- 2014-07-24 · Am J Clin Nutr · vol. 100 · número 3 · págs. 746–755
- Editorial
- Elsevier BV
- Citado
- 268 citas · más que el 98% de estudios similares · 5.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Nutritional Studies and Diet · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, cardiovascular disease, heart failure, myocardial infarction, stroke, 25-hydroxyvitamin D, calcium supplementation, RECORD trial, older adults, vitamin D3
- MeSH
- humans, myocardial infarction, vitamin d deficiency, vitamin d, risk factors, reproducibility of results, evidence-based medicine, dietary supplements, heart failure, randomized controlled trials as topic, stroke
6 autores
- John Alexander Ford🇳🇿🇬🇧University of Auckland; University of Dundee; University of Aberdeen
- Graeme MacLennan🇳🇿🇬🇧University of Auckland; University of Dundee; University of Aberdeen
- Alison Avenell🇳🇿🇬🇧University of Auckland; University of Dundee; University of Aberdeen
- Mark J Bolland🇳🇿🇬🇧University of Auckland; University of Dundee; University of Aberdeen
- Andrew B. Grey🇳🇿🇬🇧University of Auckland; University of Dundee; University of Aberdeen
- Miles D. Witham🇳🇿🇬🇧University of Auckland; University of Dundee; University of Aberdeen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low 25-hydroxyvitamin D status has been associated with increased cardiovascular events in epidemiologic studies.
Objective
We assessed whether vitamin D supplementation reduces cardiac failure, myocardial infarction (MI), and stroke through an analysis of the Randomised Evaluation of Calcium Or vitamin D (RECORD) randomized controlled trial (RCT), a systematic review, and a meta-analysis.
Design
Two analyses were undertaken. The first analysis was a trial analysis. The RECORD was a factorial RCT that compared vitamin D₃ (800 IU/d), calcium (1000 mg/d), vitamin D plus calcium, and a placebo. Cardiovascular events were collected throughout the trial and 3-y posttrial follow-up. Data were analyzed by using Cox regression. The second analysis was a systematic review. MEDLINE, EMBASE, CENTRAL, conference abstracts, and ongoing trials were searched for RCTs that evaluated vitamin D from 1980 to 2013. RCTs with ≥1 y of follow-up and participants mean or median age ≥60 y were included. Meta-analyses were based on a Bayesian fixed-effects model by using a complementary log-log link function to account for varying lengths of follow-up.
Results
In the trial analysis, we showed that, for the 5292 participants in the RECORD trial, HRs (95% CIs) for vitamin D compared with no vitamin D for cardiac failure, MI, and stroke were 0.75 (0.58, 0.97), 0.97 (0.75,1.26), and 1.06 (0.8, 1.32), respectively. Twenty-one studies met the inclusion criteria for the systematic review (n = 13,033). Estimated HRs (credible intervals) for vitamin D compared with the placebo or control for on-study events for cardiac failure, MI, and stroke were 0.82 (0.58, 1.15), 0.96 ( 0.83, 1.10), and 1.07 (0.91, 1.29), respectively.
Conclusion
Vitamin D supplementation might protect against cardiac failure in older people but does not appear to protect against MI or stroke.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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