Rabbiteye blueberry prevents osteoporosis in ovariectomized rats
Li T, Wu SM, Xu ZY, Ou-Yang S
Journal of orthopaedic surgery and research · 19 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-08-07 · J Orthop Surg Res · vol. 9 · número 1 · pág. 56
- Editorial
- BioMed Central
- Citado
- 30 citas · más que el 62% de estudios similares · 0.4× el promedio de su campo
- Referencias
- 32 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Bone Metabolism and Diseases · Bone health and osteoporosis research · Seaweed-derived Bioactive Compounds
- Palabras clave
- Ovariectomized rat, Osteoporosis, Medicine, Bone mineral, Osteoprotegerin, Bone resorption, Internal medicine, Endocrinology, Osteoclast, Bone remodeling, Receptor, Estrogen
- MeSH
- animals, humans, rats, sprague-dawley, osteoporosis, postmenopausal, disease models, animal, alkaline phosphatase, ovariectomy, bone density, female, osteoprotegerin, blueberry plants
4 autores
- Tao Li🇨🇳Third Affiliated Hospital of Southern Medical University
- Shou-Mian Wu🇨🇳Third Affiliated Hospital of Southern Medical University; Southern Medical University
- Zhiyuan Xu🇨🇳 · autor de correspondenciaThird Affiliated Hospital of Southern Medical University; Southern Medical University
- Sheng Ouyang🇨🇳 · autor de correspondenciaThird Affiliated Hospital of Southern Medical University; Southern Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
It has been forecasted that the rabbiteye blueberry could inhibit osteoporosis. However, the inhibition and prevention of osteoporosis via rabbiteye blueberry are still elusive. This study was aim to evaluate the anti-osteoporosis effects of rabbiteye blueberry in ovariectomized rats.
Methods
Thirty rats were randomly divided into three groups of ten rats each as follows: sham-operated group (SG), ovariectomized model control group (OMG), and ovariectomized rabbiteye blueberry treatment group (OBG). The blood mineral levels, the alkaline phosphatase (ALP) activity, and osteoprotegerin (OPG) level were determined. The expression analyses of type I collagen, integrin-β1, and focal adhesion kinase (FAK) were performed. Besides, the bone mineral density (BMD) and bone histomorphometry (BH) were measured.
Results
The ALP activity in SG and OBG was significantly lower than that in OMG. For the OPG level, the significant increase of OPG level in OBG was indicated compared with the other groups. The mRNA expression levels of type I collagen, integrin-β1, and FAK in OMG were significantly lower than those in other groups. The BMD in OMG were all significantly lower than those in SG and OBG. For BH, blueberry significantly improved the trabecular bone volume fraction, trabecular thickness, mean trabecular bone number, and bone formation rate, and decreased the trabecular separation, the percent of bone resorption perimeter, and mean osteoclast number in OBG compared with OMG.
Conclusions
The rabbiteye blueberries had an effective inhibition in bone resorption, bone loss, and reduction of bone strength of ovariectomized rats and could improve the BMD, osteogenic activity, and trabecular bone structure.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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