Egg consumption is associated with increased risk of ovarian cancer: Evidence from a meta-analysis of observational studies
Zeng ST, Guo L, Liu SK, Wang DH, Xi J, Huang P, Liu DT, Gao JF, Feng J, Zhang L
Clinical nutrition (Edinburgh, Scotland) · 18 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-07-23 · Clin Nutr · vol. 34 · número 4 · págs. 635–641
- Editorial
- Elsevier BV
- Citado
- 22 citas · más que el 40% de estudios similares · 0.2× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nutritional Studies and Diet · Cancer Risks and Factors · Ovarian cancer diagnosis and treatment
- Palabras clave
- egg consumption, ovarian cancer, dietary risk factors, cancer risk, dietary fat, case-control study, cohort studies
- MeSH
- humans, ovarian neoplasms, diet, risk factors, epidemiologic studies, eggs, databases, factual, female, observational studies as topic
10 autores
- Saitian Zeng🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Liang Guo🇨🇳 · autor de correspondenciaHebei Medical University; Cangzhou Central Hospital
- Shikai Liu🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Donghui Wang🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Jie Xi🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Ping Cheong Huang🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Dan-tong Liu🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Jiefan Gao🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Jing Feng🇨🇳Hebei Medical University; Cangzhou Central Hospital
- Liang Zhang🇨🇳Hebei Medical University; Cangzhou Central Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The findings of epidemiologic studies on the association between egg consumption and ovarian cancer risk remain conflicting. The aim of this meta-analysis was to investigate whether an association exists between egg intake and ovarian cancer risk in epidemiologic studies.
Methods
A literature search was carried out using PUBMED, EMBASE, and Cochrane Library Central database for all medical literature published in English-language journals up to August 2013. Before meta-analysis, between-study heterogeneity and publication bias were assessed using adequate statistical tests. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Subgroup analyses and sensitivity analysis were also performed.
Results
A total of 12 eligible studies (six case-control studies and six cohort studies) were included, involving 629,453 subjects and 3728 ovarian cancer cases. We found that high egg intake (comparing the highest with the lowest category) was associated with a significant increased risk of ovarian cancer (RR = 1.21, 95% CI [1.06, 1.38]). When we examined whether the associations differed by study type, statistically significant effect of egg intake on ovarian cancer was observed among case-control studies (RR = 1.22, 95% CI [1.03, 1.43]), but not among cohort studies (RR = 1.20, 95% CI [0.97, 1.48]).
Conclusions
Our findings suggest that egg consumption may increase ovarian cancer risk. Additional studies, especially large prospective cohort studies, are warranted to confirm the findings.
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