Calcium and vitamin D supplementation maintains parathyroid hormone and improves bone density during initial military training: a randomized, double-blind, placebo controlled trial
Gaffney-Stomberg E, Lutz LJ, Rood JC, Cable SJ, Pasiakos SM, Young AJ, McClung JP
Bone · 92 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-08-10 · Bone · vol. 68 · págs. 46–56
- Editorial
- Elsevier BV
- Citado
- 122 citas · más que el 98% de estudios similares · 7.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- De pago
- Áreas de investigación
- Bone health and osteoporosis research · Vitamin D Research Studies · Occupational Health and Performance
- Palabras clave
- calcium supplementation, vitamin D supplementation, parathyroid hormone, bone mineral density, military education, basic combat training, stress fractures, tibia, bone strength, ionized calcium, bone turnover, military personnel
- MeSH
- humans, calcium, dietary, parathyroid hormone, vitamin d, placebos, absorptiometry, photon, double-blind method, demography, body composition, bone density, dietary supplements, adult, military personnel, female, male, biomarkers
7 autores
- Erin Gaffney‐Stomberg🇺🇸U.S. Army Research Institute of Environmental Medicine; United States Army
- Laura J. Lutz🇺🇸U.S. Army Research Institute of Environmental Medicine; United States Army
- Jennifer Carlton Rood🇺🇸Pennington Biomedical Research Center; Louisiana State University System
- Sonya J. Cable🇺🇸United States Army
- Stefan M. Pasiakos🇺🇸U.S. Army Research Institute of Environmental Medicine; United States Army
- Andrew Young🇺🇸U.S. Army Research Institute of Environmental Medicine; United States Army
- James P. McClung🇺🇸 · autor de correspondenciaU.S. Army Research Institute of Environmental Medicine; United States Army
Resumen
El texto original del estudio, en el idioma en que se publicó.
Calcium and vitamin D are essential nutrients for bone health. Periods of activity with repetitive mechanical loading, such as military training, may result in increases in parathyroid hormone (PTH), a key regulator of Ca metabolism, and may be linked to the development of stress fractures. Previous studies indicate that consumption of a Ca and vitamin D supplement may reduce stress fracture risk in female military personnel during initial military training, but circulating markers of Ca and bone metabolism and measures of bone density and strength have not been determined. This randomized, double-blind, placebo-controlled trial sought to determine the effects of providing supplemental Ca and vitamin D (Ca+Vit D, 2000mg and 1000IU/d, respectively), delivered as 2 snack bars per day throughout 9weeks of Army initial military training (or basic combat training, BCT) on PTH, vitamin D status, and measures of bone density and strength in personnel undergoing BCT, as well as independent effects of BCT on bone parameters. A total of 156 men and 87 women enrolled in Army BCT (Fort Sill, OK; 34.7°N latitude) volunteered for this study. Anthropometric, biochemical, and dietary intake data were collected pre- and post-BCT. In addition, peripheral quantitative computed tomography was utilized to assess tibia bone density and strength in a subset of volunteers (n=46). Consumption of supplemental Ca+Vit D increased circulating ionized Ca (group-by-time, P=0.022), maintained PTH (group-by-time, P=0.032), and increased the osteoprotegerin:RANKL ratio (group-by-time, P=0.006). Consistent with the biochemical markers, Ca+Vit D improved vBMD (group-by-time, P=0.024) at the 4% site and cortical BMC (group-by-time, P=0.028) and thickness (group-by-time, P=0.013) at the 14% site compared to placebo. These data demonstrate the benefit of supplemental Ca and vitamin D for maintaining bone health during periods of elevated bone turnover, such as initial military training. This trial was registered with ClincialTrials.gov, NCT01617109.
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