Baru almond improves lipid profile in mildly hypercholesterolemic subjects: a randomized, controlled, crossover study
Bento AP, Cominetti C, Simões Filho A, Naves MM
Nutrition, metabolism, and cardiovascular diseases : NMCD · 39 citas
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Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de Goiás
- Gobierno
- FAPEG (Foundation of Supporting Research in Goiás State – Fundação de Amparo à Pesquisa do Estado de Goiás
Según 2 financiadores declarados.
Publicación
- Publicado
- 2014-07-18 · Nutr Metab Cardiovasc Dis · vol. 24 · número 12 · págs. 1330–1336
- Editorial
- Elsevier BV
- Citado
- 101 citas · más que el 94% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- De pago
- Áreas de investigación
- Nuts composition and effects · Lipoproteins and Cardiovascular Health · Coconut Research and Applications
- Palabras clave
- baru almond, Dipteryx alata, hypercholesterolemia, lipid profile, LDL cholesterol, non-HDL cholesterol, total cholesterol, lipid oxidation, dietary supplementation, cardiovascular risk, monounsaturated fatty acids
- MeSH
- humans, prunus, hypercholesterolemia, thiobarbituric acid reactive substances, lipids, body mass index, diet, cross-over studies, health status, body composition, oxidation-reduction, adult, middle aged, female, male, young adult
4 autores
- Ana Paula Nunes Bento🇧🇷Universidade Federal de Goiás
- Cristiane Cominetti🇧🇷Universidade Federal de Goiás
- A. Simões Filho
- Maria Margareth Veloso Naves🇧🇷 · autor de correspondenciaUniversidade Federal de Goiás
Resumen
El texto original del estudio, en el idioma en que se publicó.
Backgroud and aim
The usual consumption of nuts reduces cardiovascular diseases (CVD) risk by improving serum lipids and oxidation status. Baru almonds (Dipteryxalata Vog.), a native species of Brazilian Savannah, have considerable contents of monounsaturated fatty acids (MUFA), dietary fiber, vitamin E and zinc, which could exert positive effects in serum lipids and markers of oxidation. However, there is no study about the effect of their consumption on human health. Thus, the aim of this study was to evaluate the effect of baru almonds supplementation on lipid profile and oxidation of mildly hypercholesterolemic subjects.
Methods and results
A randomized, crossover, placebo controlled study was performed with 20 mildly hypercholesterolemic subjects (total cholesterol (TC) mean ±SEM = 5.8 ± 0.2 mmol/L). The assay had 2 periods of 6 weeks each and a 4-week washout period between the treatments. Subjects were randomly allocated in alternated periods receiving the following treatments per period: supplementation with 20 g/day of baru almonds or placebo (1 corn starch capsule/day). Compared to placebo, supplementation of baru almonds reduced TC (-8.1 ± 2.4%, P = 0.007), low-density lipoprotein cholesterol (LDL-c) (-9.4 ± 2.4%, P = 0.006) and non-high-density lipoprotein cholesterol (non-HDL-c) (-8.1 ± 3.0%, P = 0.013). There were no significant changes on the oxidation biomarkers evaluated.
Conclusion
Dietary supplementation of mildly hypercholesterolemic subjects with baru almonds improved serum lipid parameters, so that this food might be included in diets for reducing the CVD risk.
Clinical trial registry
Brazilian Registry of Clinical Trials (ReBEC) (website: http://www.ensaiosclinicos.gov.br). Register number: RBR-4zdy9p.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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