Anti-inflammatory effect of the blueberry anthocyanins malvidin-3-glucoside and malvidin-3-galactoside in endothelial cells
Huang WY, Liu YM, Wang J, Wang XN, Li CY
Molecules (Basel, Switzerland) · 101 citas
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Solo mecanismosDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio in vitro o de mecanismos (clasificado por nuestro filtro de IA)
- Estudiado en
- Células o muestras de laboratorio
- Resultado principal
- Solo mecanismos
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Government of Jiangsu Province
- Subvenciones
- National Natural Science Foundation of China (BK20141386)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2014-08-21 · Molecules · vol. 19 · número 8 · págs. 12827–12841
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 143 citas · más que el 96% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Antioxidant Activity and Oxidative Stress · Essential Oils and Antimicrobial Activity
- Palabras clave
- Malvidin, Chemistry, Biochemistry, Tumor necrosis factor alpha, Inflammation, Anthocyanin, Anti-inflammatory, VCAM-1, Galactoside, ICAM-1, Pharmacology, Food science, Intracellular, Biology, Endocrinology, Immunology
- MeSH
- humans, anthocyanins, glucosides, tumor necrosis factor-alpha, nf-kappa b, intercellular adhesion molecule-1, vascular cell adhesion molecule-1, anti-inflammatory agents, drug evaluation, preclinical, active transport, cell nucleus, i-kappa b proteins, chemokine ccl2, human umbilical vein endothelial cells, proteolysis, blueberry plants, nf-kappab inhibitor alpha
5 autores
- Wu-Yang Huang🇨🇳Jiangsu Academy of Agricultural Sciences
- Yamei Liu🇨🇳Jiangsu Academy of Agricultural Sciences
- Jian Wang🇨🇳Nanjing Agricultural University; Jiangsu Academy of Agricultural Sciences
- Xing-Na Wang🇨🇳Jiangsu Academy of Agricultural Sciences
- Chunyang Li🇨🇳 · autor de correspondenciaJiangsu Academy of Agricultural Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Blueberry fruits have a wide range of health benefits because of their abundant anthocyanins, which are natural antioxidants. The purpose of this study was to investigate the inhibitory effect of blueberry's two main anthocyanins (malvidin-3-glucoside and malvidin-3-galactoside) on inflammatory response in endothelial cells. These two malvidin glycosides could inhibit tumor necrosis factor-alpha (TNF-α) induced increases of monocyte chemotactic protein-1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1) production both in the protein and mRNA levels in a concentration-dependent manner. Mv-3-glc at the concentration of 1 μM could inhibit 35.9% increased MCP-1, 54.4% ICAM-1, and 44.7% VCAM-1 protein in supernatant, as well as 9.88% MCP-1 and 48.6% ICAM-1 mRNA expression (p<0.05). In addition, they could decrease IκBα degradation (Mv-3-glc, Mv-3-gal, and their mixture at the concentration of 50 μM had the inhibition rate of 84.8%, 75.3%, and 43.2%, respectively, p<0.01) and block the nuclear translocation of p65, which suggested their anti-inflammation mechanism was mediated by the nuclear factor-kappa B (NF-κB) pathway. In general malvidin-3-glucoside had better anti-inflammatory effect than malvidin-3-galactoside. These results indicated that blueberry is good resource of anti-inflammatory anthocyanins, which can be promising molecules for the development of nutraceuticals to prevent chronic inflammation in many diseases.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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