Dietary linoleic acid and risk of coronary heart disease: a systematic review and meta-analysis of prospective cohort studies
Farvid MS, Ding M, Pan A, Sun Q, Chiuve SE, Steffen LM, Willett WC, Hu FB
Circulation · 390 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Gobierno
- NHLBI NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (HL60712); National Cancer Institute (U01 CA167552); National Cancer Institute (P01 CA055075.); National Cancer Institute (UM1-CA-167552); National Institute of Diabetes and Digestive and Kidney Diseases (R01-DK058845); National Heart, Lung, and Blood Institute (R01 HL060712)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2014-08-27 · Circulation · vol. 130 · número 18 · págs. 1568–1578
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 564 citas · más que el 97% de estudios similares · 6.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 48 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Antioxidant Activity and Oxidative Stress · Liver Disease Diagnosis and Treatment
- Palabras clave
- Medicine, Coronary heart disease, Meta-analysis, Prospective cohort study, Linoleic acid, Cohort study, Internal medicine, Cardiology, Fatty acid
- MeSH
- humans, coronary disease, dietary fats, linoleic acid, risk factors, prospective studies, observational studies as topic
8 autores
- Maryam Sadat Farvid🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Ming Ding🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- An Pan🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Qi Sun🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Stephanie E. Chiuve🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Lyn M. Steffen🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Walter Churchill Willett🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
- Frank B. Hu🇺🇸🇸🇬🇮🇷Brigham and Women's Hospital; University of Minnesota; Harvard University; National University of Singapore; National Nutrition and Food Technology Research Institute; National University Health System; Shahid Beheshti University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Previous studies on intake of linoleic acid (LA), the predominant n-6 fatty acid, and coronary heart disease (CHD) risk have generated inconsistent results. We performed a systematic review and meta-analysis of prospective cohort studies to summarize the evidence regarding the relation of dietary LA intake and CHD risk.
Methods and results
We searched MEDLINE and EMBASE databases through June 2013 for prospective cohort studies that reported the association between dietary LA and CHD events. In addition, we used unpublished data from cohort studies in a previous pooling project. We pooled the multivariate-adjusted relative risk (RR) to compare the highest with the lowest categories of LA intake using fixed-effect meta-analysis. We identified 13 published and unpublished cohort studies with a total of 310 602 individuals and 12 479 total CHD events, including 5882 CHD deaths. When the highest category was compared with the lowest category, dietary LA was associated with a 15% lower risk of CHD events (pooled RR, 0.85; 95% confidence intervals, 0.78-0.92; I(2)=35.5%) and a 21% lower risk of CHD deaths (pooled RR, 0.79; 95% confidence intervals, 0.71-0.89; I(2)=0.0%). A 5% of energy increment in LA intake replacing energy from saturated fat intake was associated with a 9% lower risk of CHD events (RR, 0.91; 95% confidence intervals, 0.87-0.96) and a 13% lower risk of CHD deaths (RR, 0.87; 95% confidence intervals, 0.82-0.94).
Conclusions
In prospective observational studies, dietary LA intake is inversely associated with CHD risk in a dose-response manner. These data provide support for current recommendations to replace saturated fat with polyunsaturated fat for primary prevention of CHD.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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