Cruciferous vegetables have variable effects on biomarkers of systemic inflammation in a randomized controlled trial in healthy young adults
Navarro SL, Schwarz Y, Song X, Wang CY, Chen C, Trudo SP, Kristal AR, Kratz M, Eaton DL, Lampe JW
The Journal of nutrition · 37 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Fred Hutchinson Cancer Research Center
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (R56 CA70913); National Cancer Institute (R01 CA70913); National Cancer Institute (T32CA09168); National Cancer Institute (R25 CA 94880); National Cancer Institute (CA94880); National Cancer Institute (R01CA142695); National Cancer Institute (R25 CA094880); National Institutes of Health (T32-CA09168); National Institutes of Health (R25 CA94880); National Cancer Institute (P30CA015704); National Institute of Diabetes and Digestive and Kidney Diseases (P30DK017047)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2014-08-28 · J Nutr · vol. 144 · número 11 · págs. 1850–1857
- Editorial
- Elsevier BV
- Citado
- 49 citas · más que el 74% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms · Phytochemicals and Antioxidant Activities
- Palabras clave
- cruciferous vegetables, isothiocyanates, systemic inflammation, inflammatory markers, interleukin-6, interleukin-8, C-reactive protein, TNF-α, soluble TNF receptors, GSTM1 genotype, dietary intervention, healthy young adults, genetic polymorphism
- MeSH
- humans, brassicaceae, vegetables, inflammation, glutathione transferase, diet, cross-over studies, gene expression regulation, adult, female, male, young adult, biomarkers
10 autores
- Sandi L. Navarro🇺🇸 · autor de correspondenciaFred Hutch Cancer Center
- Yvonne Schwarz🇺🇸Fred Hutch Cancer Center
- Xiaoling Song🇺🇸Fred Hutch Cancer Center
- Ching‐Yun Wang🇺🇸Fred Hutch Cancer Center
- Chu Chen🇺🇸Fred Hutch Cancer Center
- Sabrina P. Trudo🇺🇸University of Minnesota
- Alan R. Kristal🇺🇸Fred Hutch Cancer Center
- Mario Kratz🇺🇸Fred Hutch Cancer Center
- David L. Eaton🇺🇸University of Washington
- Johanna W. Lampe🇺🇸Fred Hutch Cancer Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Isothiocyanates in cruciferous vegetables modulate signaling pathways critical to carcinogenesis, including nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), a central regulator of inflammation. Glutathione S-transferase (GST) M1 and GSTT1 metabolize isothiocyanates; genetic variants may result in differences in biologic response.
Objective
The objective of this study was to test whether consumption of cruciferous or cruciferous plus apiaceous vegetables altered serum concentrations of interleukin (IL)-6, IL-8, C-reactive protein (CRP), tumor necrosis factor (TNF) α, and soluble TNF receptor (sTNFR) I and II, and whether this response was GSTM1/GSTT1 genotype dependent.
Methods
In a randomized crossover trial, healthy men (n = 32) and women (n = 31) aged 20-40 y consumed 4 14-d controlled diets: basal (vegetable-free), single-dose cruciferous (1xC) [7 g vegetables/kg body weight (BW)], double-dose cruciferous (2xC) (14 g/kg BW), and cruciferous plus apiaceous (carrot family) (1xC+A) vegetables (7 and 4 g/kg BW, respectively), with a 21-d washout period between each intervention. Urinary isothiocyanate excretion was also evaluated as a marker of systemic isothiocyanate exposure. Fasting morning blood and urine samples were collected on days 0 and 14 and analyzed.
Results
IL-6 concentrations were significantly lower on day 14 of the 2xC and 1xC+A diets than with the basal diet [-19% (95% CI: -30%, -0.1%) and -20% (95% CI: -31%, -0.7%), respectively]. IL-8 concentrations were higher after the 1xC+A diet (+16%; 95% CI: 4.2%, 35.2%) than after the basal diet. There were no effects of diet on CRP, TNF-α, or sTNFRI or II. There were significant differences between GSTM1-null/GSTT1+ individuals for several biomarkers in response to 1xC+A compared with basal diets (CRP: -37.8%; 95% CI: -58.0%, -7.4%; IL-6: -48.6%; 95% CI: -49.6%, -12.0%; IL-8: 16.3%; 95% CI: 6.7%, 57.7%) and with the 2xC diet compared with the basal diet (IL-8: -33.2%; 95% CI: -43.0%, -1.4%; sTNFRI: -7.5%; 95% CI: -12.7%, -2.3%). There were no significant reductions in biomarker concentrations in response to diet among GSTM1+/GSTT1+ or GSTM1-null/GSTT1-null individuals. Twenty-four-hour urinary isothiocyanate excretion was not associated with any of the inflammation markers overall; however, IL-6 was inversely associated with total isothiocyanate excretion in GSTM1-null/GSTT1-null individuals (β = -0.12; 95% CI: -0.19, -0.05).
Conclusions
In this young, healthy population, consumption of cruciferous and apiaceous vegetables reduced circulating IL-6; however, results for other biomarkers of inflammation were not consistent.
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