Omega-3 fatty acid and ADHD: blood level analysis and meta-analytic extension of supplementation trials
Hawkey E, Nigg JT
Clinical psychology review · 111 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Oregon Health and Science University
- Gobierno
- National Institute of Mental Health
- Gobierno
- NIMH NIH HHS
- Universidad u hospital
- OHSU internal institutional funds
- Subvenciones
- National Institute of Mental Health (R01 MH059105); National Institute of Mental Health (R37MH059105); National Institute of Mental Health (R01 MH115357)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2014-06-02 · Clin Psychol Rev · vol. 34 · número 6 · págs. 496–505
- Editorial
- Elsevier BV
- Citado
- 160 citas · más que el 99% de estudios similares · 13.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Fatty Acid Research and Health · Attention Deficit Hyperactivity Disorder · Developmental and Educational Neuropsychology
- Palabras clave
- omega-3 fatty acids, attention deficit hyperactivity disorder, serum lipids, hyperactivity, inattention, children, dietary supplementation, parent and teacher ratings
- MeSH
- humans, fatty acids, omega-3, attention deficit disorder with hyperactivity, adolescent, child
2 autores
- Elizabeth J. Hawkey🇺🇸Oregon Health & Science University
- Joel T. Nigg🇺🇸 · autor de correspondenciaOregon Health & Science University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Unlabelled
Interest in the value of omega-3 (n-3) fatty acid supplementation for treatment of ADHD remains high. No prior meta-analysis has examined whether ADHD is associated with alterations in blood lipid levels and meta-analyses of supplementation have reached conflicting conclusions.
Methods
We report two new meta-analyses. Study 1 examined blood levels of omega-3 fatty acids in relation to ADHD. Study 2 examined a larger sample of randomized intervention trials than previously reported.
Results
Study 1 included 9 studies (n=586) and found lower overall blood levels of n-3 in individuals with ADHD versus controls (g=0.42, 95% CI=0.26-0.59; p<.001). Study 2 included 16 studies (n=1408) and found that n-3 supplementation improved ADHD composite symptoms; using the best available rating and reporter (g=0.26, 95% CI=0.15-0.37; p<.001). Supplementation showed reliable effects on hyperactivity by parent and teacher report, but reliable effects for inattention only by parent report.
Conclusions
Omega-3 levels are reduced in children with ADHD. Dietary supplementation appears to create modest improvements in symptoms. There is sufficient evidence to consider omega-3 fatty acids as a possible supplement to established therapies. However it remains unclear whether such intervention should be confined to children with below normal blood levels.
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