Effect of acute dietary nitrate intake on maximal knee extensor speed and power in healthy men and women
Coggan AR, Leibowitz JL, Kadkhodayan A, Thomas DP, Ramamurthy S, Spearie CA, Waller S, Farmer M, Peterson LR
Nitric oxide : biology and chemistry · 135 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Institute of Clinical and Translational Sciences
- Gobierno
- National Institutes of Health
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- National Institutes of Health (NIH)
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1-TR-000448); National Institutes of Health (UL1‐TR000448)
Según 5 financiadores declarados.
Publicación
- Publicado
- 2014-09-06 · Nitric Oxide · vol. 48 · págs. 16–21
- Editorial
- Elsevier BV
- Citado
- 158 citas · más que el 99% de estudios similares · 18.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Cardiovascular and exercise physiology · Muscle metabolism and nutrition · Exercise and Physiological Responses
- Palabras clave
- dietary nitrate, beetroot juice, nitric oxide bioavailability, knee extensor power, muscle shortening velocity, isokinetic strength, muscle contractility
- MeSH
- muscle, skeletal, knee joint, humans, nitrates, nitric oxide, biological availability, muscle fatigue, muscle contraction, torque, dietary supplements, adult, middle aged, female, male, muscle strength, young adult
9 autores
- Andrew R. Coggan🇺🇸 · autor de correspondenciaWashington University in St. Louis
- Joshua L. Leibowitz🇺🇸Washington University in St. Louis
- Ana Kadkhodayan🇺🇸Washington University in St. Louis
- Deepak P. Thomas🇺🇸Washington University in St. Louis
- Sujata Ramamurthy🇺🇸Washington University in St. Louis
- Catherine Anderson Spearie🇺🇸Washington University in St. Louis
- Suzanne Waller🇺🇸Washington University in St. Louis
- Marsha S. Farmer🇺🇸Washington University in St. Louis
- Linda R. Peterson🇺🇸Washington University in St. Louis
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nitric oxide (NO) has been demonstrated to enhance the maximal shortening velocity and maximal power of rodent muscle. Dietary nitrate (NO3(-)) intake has been demonstrated to increase NO bioavailability in humans. We therefore hypothesized that acute dietary NO3(-) intake (in the form of a concentrated beetroot juice (BRJ) supplement) would improve muscle speed and power in humans. To test this hypothesis, healthy men and women (n = 12; age = 22-50 y) were studied using a randomized, double-blind, placebo-controlled crossover design. After an overnight fast, subjects ingested 140 mL of BRJ either containing or devoid of 11.2 mmol of NO3(-). After 2 h, knee extensor contractile function was assessed using a Biodex 4 isokinetic dynamometer. Breath NO levels were also measured periodically using a Niox Mino analyzer as a biomarker of whole-body NO production. No significant changes in breath NO were observed in the placebo trial, whereas breath NO rose by 61% (P < 0.001; effect size = 1.19) after dietary NO3(-) intake. This was accompanied by a 4% (P < 0.01; effect size = 0.74) increase in peak knee extensor power at the highest angular velocity tested (i.e., 6.28 rad/s). Calculated maximal knee extensor power was therefore greater (i.e., 7.90 ± 0.59 vs. 7.44 ± 0.53 W/kg; P < 0.05; effect size = 0.63) after dietary NO3(-) intake, as was the calculated maximal velocity (i.e., 14.5 ± 0.9 vs. 13.1 ± 0.8 rad/s; P < 0.05; effect size = 0.67). No differences in muscle function were observed during 50 consecutive knee extensions performed at 3.14 rad/s. We conclude that acute dietary NO3(-) intake increases whole-body NO production and muscle speed and power in healthy men and women.
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